O-glycans truncation modulates gastric cancer cell signaling and transcription leading to a more aggressive phenotype

Changes in glycosylation are known to play critical roles during gastric carcinogenesis. Expression of truncated O-glycans, such as the Sialyl-Tn (STn) antigen, is a common feature shared by many cancers and is associated with cancer aggressiveness and poor-prognosis. Glycoengineered cell lines were...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	EBioMedicine 2019-02, Vol.40, p.349-362
Hauptverfasser:	Freitas, Daniela, Campos, Diana, Gomes, Joana, Pinto, Filipe, Macedo, Joana A., Matos, Rita, Mereiter, Stefan, Pinto, Marta T., Polónia, António, Gartner, Fátima, Magalhães, Ana, Reis, Celso A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Gastric cancer Poor-survival Research paper RUNX1 Sialyl-Tn SRPX2
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!