Beta-Cryptoxanthin Inhibits Lipopolysaccharide-Induced Osteoclast Differentiation and Bone Resorption via the Suppression of Inhibitor of NF-κB Kinase Activity

Beta-cryptoxanthin (β-cry) is a typical carotenoid found abundantly in fruit and vegetables such as the Japanese mandarin orange, persimmon, papaya, paprika, and carrot, and exerts various biological activities (e.g., antioxidant effects). We previously reported that β-cry suppressed lipopolysacchar...

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Veröffentlicht in:	Nutrients 2019-02, Vol.11 (2), p.368
Hauptverfasser:	Hirata, Narumi, Ichimaru, Ryota, Tominari, Tsukasa, Matsumoto, Chiho, Watanabe, Kenta, Taniguchi, Keita, Hirata, Michiko, Ma, Sihui, Suzuki, Katsuhiko, Grundler, Florian M W, Miyaura, Chisato, Inada, Masaki
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine triphosphate animal models Animals antioxidant activity beta-cryptoxanthin Beta-Cryptoxanthin - pharmacology binding sites Biomedical materials Bone growth Bone resorption Bone Resorption - metabolism Carotenoids carrots Cathepsin K Cbfa-1 protein Cell differentiation Cell Differentiation - drug effects computer simulation Cyclooxygenase-2 Differentiation enzyme activity Enzyme inhibitors Fibroblasts fruits Gene expression Gram-negative bacteria Growth factors Gum disease IKappaB kinase in vitro studies Inflammation Inflammatory response Kinases Ligands Lipopolysaccharides Lipopolysaccharides - pharmacology Male mandarins messenger RNA Mice Mineralization NF-κB protein Osteoblastogenesis Osteoblasts Osteoclastogenesis osteoclasts Osteoclasts - cytology Osteoclasts - drug effects Osteogenesis paprika periodontitis persimmons Prostaglandin E2 prostaglandin synthase Prostaglandin-E synthase prostaglandins Proteins RANK Ligand - antagonists & inhibitors RANK Ligand - metabolism RAW 264.7 Cells Science Stem cells TLR4 protein Toll-like receptors TRANCE protein transcription factor NF-kappa B transcriptional activation
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