Eucommia ulmoides Leaf Extract Ameliorates Steatosis Induced by High-fat Diet in Rats by Increasing Lysosomal Function
The recent discovery that the impairment of autophagic flux in non-alcoholic fatty liver disease (NAFLD) might be a strong determining factor in steatosis suggests the potential of therapeutic control of autophagic flux with natural agents in restoring NAFLD. We investigated the potential of leaf ex...
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| Veröffentlicht in: | Nutrients 2019-02, Vol.11 (2), p.426 |
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| creator | Lee, Geum-Hwa Lee, Hwa-Young Park, Sun-Ah Shin, Tai-Sun Chae, Han-Jung |
| description | The recent discovery that the impairment of autophagic flux in non-alcoholic fatty liver disease (NAFLD) might be a strong determining factor in steatosis suggests the potential of therapeutic control of autophagic flux with natural agents in restoring NAFLD. We investigated the potential of
leaf extract (EUL) to control dyslipidemia in NAFLD. EUL supplementation (200 mg/kg) promoted recovery from high fat diet (HFD)-induced lipid dysmetabolism. This hepatoprotective efficacy was accompanied by suppression of endoplasmic reticulum (ER) stress, enhancing lysosomal functions, and thereby increasing autophagic flux. We found a strong indication that inhibition of the mTOR-ER stress pathway was related to the enhanced autophagic flux. However, the direct antioxidative effect of EUL on cytoprotection cannot be ruled out as a significant contributing factor in NAFLD. Our findings will aid in further elucidating the mechanism of the anti-steatosis activity of EUL and highlight the therapeutic potential of EUL in the treatment of NAFLD. |
| doi_str_mv | 10.3390/nu11020426 |
| format | Article |
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leaf extract (EUL) to control dyslipidemia in NAFLD. EUL supplementation (200 mg/kg) promoted recovery from high fat diet (HFD)-induced lipid dysmetabolism. This hepatoprotective efficacy was accompanied by suppression of endoplasmic reticulum (ER) stress, enhancing lysosomal functions, and thereby increasing autophagic flux. We found a strong indication that inhibition of the mTOR-ER stress pathway was related to the enhanced autophagic flux. However, the direct antioxidative effect of EUL on cytoprotection cannot be ruled out as a significant contributing factor in NAFLD. Our findings will aid in further elucidating the mechanism of the anti-steatosis activity of EUL and highlight the therapeutic potential of EUL in the treatment of NAFLD.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu11020426</identifier><identifier>PMID: 30781653</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; antioxidant activity ; Antioxidants ; Apoptosis ; Autophagy ; Autophagy - drug effects ; Cholesterol ; Diet, High-Fat - adverse effects ; Dyslipidemia ; Endoplasmic reticulum ; Endoplasmic Reticulum Stress - drug effects ; Eucommia ulmoides ; Eucommiaceae ; Fatty liver ; Fatty Liver - drug therapy ; Fatty Liver - etiology ; Fluctuations ; Flux ; Food ; High fat diet ; hyperlipidemia ; Insulin resistance ; Laboratory animals ; leaf extracts ; Leaves ; Lipids ; Liver diseases ; Lysosomes - drug effects ; Medical research ; Metabolism ; Natural & organic foods ; Non-alcoholic Fatty Liver Disease - drug therapy ; Non-alcoholic Fatty Liver Disease - etiology ; Nutrition research ; Pharmacology ; Phytotherapy - methods ; Plant extracts ; Plant Extracts - pharmacology ; Plant Leaves ; Proteins ; Rats ; Steatosis ; therapeutics ; TOR protein</subject><ispartof>Nutrients, 2019-02, Vol.11 (2), p.426</ispartof><rights>2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 by the authors. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-8eb7805d87c745c94b42224180a3bf72d4209b21976faf1390387023a98b48243</citedby><cites>FETCH-LOGICAL-c439t-8eb7805d87c745c94b42224180a3bf72d4209b21976faf1390387023a98b48243</cites><orcidid>0000-0003-4190-9889</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412281/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412281/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30781653$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Geum-Hwa</creatorcontrib><creatorcontrib>Lee, Hwa-Young</creatorcontrib><creatorcontrib>Park, Sun-Ah</creatorcontrib><creatorcontrib>Shin, Tai-Sun</creatorcontrib><creatorcontrib>Chae, Han-Jung</creatorcontrib><title>Eucommia ulmoides Leaf Extract Ameliorates Steatosis Induced by High-fat Diet in Rats by Increasing Lysosomal Function</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>The recent discovery that the impairment of autophagic flux in non-alcoholic fatty liver disease (NAFLD) might be a strong determining factor in steatosis suggests the potential of therapeutic control of autophagic flux with natural agents in restoring NAFLD. We investigated the potential of
leaf extract (EUL) to control dyslipidemia in NAFLD. EUL supplementation (200 mg/kg) promoted recovery from high fat diet (HFD)-induced lipid dysmetabolism. This hepatoprotective efficacy was accompanied by suppression of endoplasmic reticulum (ER) stress, enhancing lysosomal functions, and thereby increasing autophagic flux. We found a strong indication that inhibition of the mTOR-ER stress pathway was related to the enhanced autophagic flux. However, the direct antioxidative effect of EUL on cytoprotection cannot be ruled out as a significant contributing factor in NAFLD. Our findings will aid in further elucidating the mechanism of the anti-steatosis activity of EUL and highlight the therapeutic potential of EUL in the treatment of NAFLD.</description><subject>Animals</subject><subject>antioxidant activity</subject><subject>Antioxidants</subject><subject>Apoptosis</subject><subject>Autophagy</subject><subject>Autophagy - drug effects</subject><subject>Cholesterol</subject><subject>Diet, High-Fat - adverse effects</subject><subject>Dyslipidemia</subject><subject>Endoplasmic reticulum</subject><subject>Endoplasmic Reticulum Stress - drug effects</subject><subject>Eucommia ulmoides</subject><subject>Eucommiaceae</subject><subject>Fatty liver</subject><subject>Fatty Liver - drug therapy</subject><subject>Fatty Liver - etiology</subject><subject>Fluctuations</subject><subject>Flux</subject><subject>Food</subject><subject>High fat diet</subject><subject>hyperlipidemia</subject><subject>Insulin resistance</subject><subject>Laboratory animals</subject><subject>leaf extracts</subject><subject>Leaves</subject><subject>Lipids</subject><subject>Liver diseases</subject><subject>Lysosomes - drug effects</subject><subject>Medical research</subject><subject>Metabolism</subject><subject>Natural & organic foods</subject><subject>Non-alcoholic Fatty Liver Disease - drug therapy</subject><subject>Non-alcoholic Fatty Liver Disease - etiology</subject><subject>Nutrition research</subject><subject>Pharmacology</subject><subject>Phytotherapy - methods</subject><subject>Plant extracts</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Leaves</subject><subject>Proteins</subject><subject>Rats</subject><subject>Steatosis</subject><subject>therapeutics</subject><subject>TOR protein</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkU9r3DAQxUVoSUKaSz9AEfRSCk6lkSzJl0JIN83CQqF_zkKW5Y2CLaWWFLrfvlqSJmlPncsMvB-PmXkIvabkjLGOfAiFUgKEgzhAx0AkNEJw9uLZfIROU7oh-5JECnaIjhiRioqWHaO7VbFxnr3BZZqjH1zCG2dGvPqVF2MzPp_d5ONichW-ZWdyTD7hdRiKdQPud_jKb6-b0WT8ybuMfcBfTU57YR3s4kzyYYs3uxRTnM2EL0uw2cfwCr0czZTc6UM_QT8uV98vrprNl8_ri_NNYznrcqNcLxVpByWt5K3teM8BgFNFDOtHCQMH0vVAOylGM9L6D6YkAWY61XMFnJ2gj_e-t6Wf3WBdqGdN-nbxs1l2Ohqv_1aCv9bbeKcFpwCKVoN3DwZL_Flcynr2ybppMsHFknSFREdEB_-BUsUpJwpURd_-g97EsoT6CQ2MttAJaEml3t9TdokpLW583JsSvQ9fP4Vf4TfPL31E_0TNfgOnU6ik</recordid><startdate>20190218</startdate><enddate>20190218</enddate><creator>Lee, Geum-Hwa</creator><creator>Lee, Hwa-Young</creator><creator>Park, Sun-Ah</creator><creator>Shin, Tai-Sun</creator><creator>Chae, Han-Jung</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4190-9889</orcidid></search><sort><creationdate>20190218</creationdate><title>Eucommia ulmoides Leaf Extract Ameliorates Steatosis Induced by High-fat Diet in Rats by Increasing Lysosomal Function</title><author>Lee, Geum-Hwa ; 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We investigated the potential of
leaf extract (EUL) to control dyslipidemia in NAFLD. EUL supplementation (200 mg/kg) promoted recovery from high fat diet (HFD)-induced lipid dysmetabolism. This hepatoprotective efficacy was accompanied by suppression of endoplasmic reticulum (ER) stress, enhancing lysosomal functions, and thereby increasing autophagic flux. We found a strong indication that inhibition of the mTOR-ER stress pathway was related to the enhanced autophagic flux. However, the direct antioxidative effect of EUL on cytoprotection cannot be ruled out as a significant contributing factor in NAFLD. Our findings will aid in further elucidating the mechanism of the anti-steatosis activity of EUL and highlight the therapeutic potential of EUL in the treatment of NAFLD.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>30781653</pmid><doi>10.3390/nu11020426</doi><orcidid>https://orcid.org/0000-0003-4190-9889</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals antioxidant activity Antioxidants Apoptosis Autophagy Autophagy - drug effects Cholesterol Diet, High-Fat - adverse effects Dyslipidemia Endoplasmic reticulum Endoplasmic Reticulum Stress - drug effects Eucommia ulmoides Eucommiaceae Fatty liver Fatty Liver - drug therapy Fatty Liver - etiology Fluctuations Flux Food High fat diet hyperlipidemia Insulin resistance Laboratory animals leaf extracts Leaves Lipids Liver diseases Lysosomes - drug effects Medical research Metabolism Natural & organic foods Non-alcoholic Fatty Liver Disease - drug therapy Non-alcoholic Fatty Liver Disease - etiology Nutrition research Pharmacology Phytotherapy - methods Plant extracts Plant Extracts - pharmacology Plant Leaves Proteins Rats Steatosis therapeutics TOR protein |
| title | Eucommia ulmoides Leaf Extract Ameliorates Steatosis Induced by High-fat Diet in Rats by Increasing Lysosomal Function |
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