A bacteria-based genetic assay detects prion formation

Prions are infectious, self-propagating protein aggregates that are notorious for causing devastating neurodegenerative diseases in mammals. Recent evidence supports the existence of prions in bacteria. However, the evaluation of candidate bacterial prion-forming proteins has been hampered by the la...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-03, Vol.116 (10), p.4605-4610
Hauptverfasser:	Fleming, Eleanor, Yuan, Andy H., Heller, Danielle M., Hochschild, Ann
Format:	Artikel
Sprache:	eng
Schlagworte:	Assaying Bacteria Biological Sciences Campylobacter Campylobacter - genetics Campylobacter - metabolism ClpB protein Deoxyribonucleic acid DNA DNA-binding protein Domains Escherichia coli - genetics Escherichia coli - metabolism Genes, Reporter Genetic Techniques Neurodegenerative diseases Neurological diseases Prion protein Prions Prions - genetics Prions - metabolism Proteins Self propagation Single-stranded DNA Single-stranded DNA-binding protein Transcription, Genetic Yeast Yeasts
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