Loss of Angiotensin‐Converting Enzyme 2 Exacerbates Diabetic Retinopathy by Promoting Bone Marrow Dysfunction

Angiotensin‐converting enzyme 2 (ACE2) is the primary enzyme of the vasoprotective axis of the renin angiotensin system (RAS). We tested the hypothesis that loss of ACE2 would exacerbate diabetic retinopathy by promoting bone marrow dysfunction. ACE2–/y were crossed with Akita mice, a model of type...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2018-09, Vol.36 (9), p.1430-1440
Hauptverfasser:	Duan, Yaqian, Beli, Eleni, Li Calzi, Sergio, Quigley, Judith L., Miller, Rehae C., Moldovan, Leni, Feng, Dongni, Salazar, Tatiana E., Hazra, Sugata, Al‐Sabah, Jude, Chalam, Kakarla V., Phuong Trinh, Thao Le, Meroueh, Marya, Markel, Troy A., Murray, Matthew C., Vyas, Ruchi J., Boulton, Michael E., Parsons‐Wingerter, Patricia, Oudit, Gavin Y., Obukhov, Alexander G., Grant, Maria B.
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 Angiotensin Angiotensin-Converting Enzyme 2 Animals Bone marrow Bone Marrow - metabolism Capillaries CD34 CD34 antigen Cell migration Cell proliferation Cells (biology) Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetic retinopathy Diabetic Retinopathy - chemically induced Disease Models, Animal Electroretinography Enzymes Hematopoiesis Hematopoietic progenitors Hematopoietic stem cells Humans Mice mRNA Myelopoiesis Peptidyl-Dipeptidase A - adverse effects Peptidyl-Dipeptidase A - deficiency Photography Progenitor cells Reduction Renin Retina Retinopathy Stem cell transplantation Stem cells
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