Single-molecule 3D imaging of human plasma intermediate-density lipoproteins reveals a polyhedral structure

Intermediate-density lipoproteins (IDLs), the remnants of very-low-density lipoproteins via lipolysis, are rich in cholesteryl ester and are associated with cardiovascular disease. Despite pharmacological interest in IDLs, their three-dimensional (3D) structure is still undetermined due to their var...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular and cell biology of lipids 2019-03, Vol.1864 (3), p.260-270
Hauptverfasser:	Lei, Dongsheng, Yu, Yadong, Kuang, Yu-Lin, Liu, Jianfang, Krauss, Ronald M., Ren, Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	3D structure Apolipoprotein A-I - metabolism Apolipoproteins B - metabolism binding capacity cardiovascular diseases Cholesterol Ester Transfer Proteins - metabolism Cholesterol Esters - metabolism cholesteryl ester transfer protein Cryo-electron microscopy Cryoelectron Microscopy - methods Electron Microscope Tomography - methods Healthy Volunteers high density lipoprotein Humans hydrophobicity Imaging, Three-Dimensional - methods Individual-particle electron tomography Intermediate-density lipoprotein IPET lipolysis Lipolysis - physiology Lipoproteins - metabolism Lipoproteins, HDL - metabolism Lipoproteins, IDL - chemistry Lipoproteins, IDL - metabolism Lipoproteins, IDL - physiology Lipoproteins, LDL - metabolism Lipoproteins, VLDL - metabolism Plasma - diagnostic imaging Single Molecule Imaging - methods tomography
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