Integrative Bioinformatics Analysis Reveals Potential Gene Biomarkers and Analysis of Function in Human Degenerative Disc Annulus Fibrosus Cells
Low back pain is a major cause of disability worldwide. Although numerous potential biomarkers for the early diagnosis or treatment of intervertebral disc degeneration (IDD) have been identified subsequent to the development of molecular biology technologies, the mechanisms of IDD remain unknown. Pu...
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| Veröffentlicht in: | BioMed research international 2019-01, Vol.2019 (2019), p.1-8 |
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| creator | Tao, Han Xuepeng, Li Long, Liang Wang, Shangquan Jie, Yu Wei, Xu Zhan, Jia-Wen Zhu, Liguo Feng, Minshan Xunlu, Yin He, Yin |
| description | Low back pain is a major cause of disability worldwide. Although numerous potential biomarkers for the early diagnosis or treatment of intervertebral disc degeneration (IDD) have been identified subsequent to the development of molecular biology technologies, the mechanisms of IDD remain unknown. Published studies found the unbalance of anabolism and catabolism of annulus fibrosus (AF) played an important role in it. The present study was aimed to identify the potential targets and signaling pathways of IDD, through the combined analysis of differential expression and based on the Gene Expression Omnibus (GEO) dataset from NCBI. PPI Networks Analysis indicated that MMP2 and AGE-RAGE signaling pathway and estrogen signaling pathway may play important roles in initiation and development of IDD. This study forecasted the pathogenesis molecular mechanism of IDD and the potential prognostic and diagnostic biomarkers, but we need to make further molecular biological experiments to confirm our assumptions. |
| doi_str_mv | 10.1155/2019/9890279 |
| format | Article |
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Although numerous potential biomarkers for the early diagnosis or treatment of intervertebral disc degeneration (IDD) have been identified subsequent to the development of molecular biology technologies, the mechanisms of IDD remain unknown. Published studies found the unbalance of anabolism and catabolism of annulus fibrosus (AF) played an important role in it. The present study was aimed to identify the potential targets and signaling pathways of IDD, through the combined analysis of differential expression and based on the Gene Expression Omnibus (GEO) dataset from NCBI. PPI Networks Analysis indicated that MMP2 and AGE-RAGE signaling pathway and estrogen signaling pathway may play important roles in initiation and development of IDD. This study forecasted the pathogenesis molecular mechanism of IDD and the potential prognostic and diagnostic biomarkers, but we need to make further molecular biological experiments to confirm our assumptions.</description><identifier>ISSN: 2314-6133</identifier><identifier>ISSN: 2314-6141</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2019/9890279</identifier><identifier>PMID: 30915367</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Annuli ; Annulus Fibrosus - metabolism ; Annulus Fibrosus - pathology ; Antigens, Neoplasm - genetics ; Arthritis ; Back pain ; Backache ; Bioinformatics ; Biological markers ; Biomarkers ; Biomarkers - metabolism ; Biomechanics ; Biosynthesis ; Care and treatment ; Catabolism ; Cell adhesion & migration ; Computational Biology ; Cytochrome ; Degeneration ; Diagnostic systems ; Estrogen ; Estrogens ; Gelatinase A ; Gene expression ; Gene Expression Profiling ; Gene Expression Regulation ; Humans ; Influenza ; Intervertebral Disc - physiopathology ; Intervertebral Disc Degeneration - diagnosis ; Intervertebral Disc Degeneration - genetics ; Intervertebral Disc Degeneration - pathology ; Intervertebral discs ; Joint surgery ; Low back pain ; Matrix Metalloproteinase 2 - genetics ; Metabolism ; Mitogen-Activated Protein Kinases - genetics ; Molecular biology ; Pain ; Pathogenesis ; Polymorphism ; Prognosis ; Proteins ; Signal transduction ; Signaling ; Target recognition</subject><ispartof>BioMed research international, 2019-01, Vol.2019 (2019), p.1-8</ispartof><rights>Copyright © 2019 Yin Xunlu et al.</rights><rights>COPYRIGHT 2019 John Wiley & Sons, Inc.</rights><rights>Copyright © 2019 Yin Xunlu et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2019 Yin Xunlu et al. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-13dc2272feafa522d3e45cbd81dc306d40cf3a3d861ce98ec8b531c9cb3dce343</citedby><cites>FETCH-LOGICAL-c499t-13dc2272feafa522d3e45cbd81dc306d40cf3a3d861ce98ec8b531c9cb3dce343</cites><orcidid>0000-0003-1130-3085 ; 0000-0001-7193-8547 ; 0000-0002-3388-4215 ; 0000-0003-1748-418X ; 0000-0002-5845-1125 ; 0000-0001-6723-9604</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409044/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409044/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30915367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Sun, Zhirong</contributor><creatorcontrib>Tao, Han</creatorcontrib><creatorcontrib>Xuepeng, Li</creatorcontrib><creatorcontrib>Long, Liang</creatorcontrib><creatorcontrib>Wang, Shangquan</creatorcontrib><creatorcontrib>Jie, Yu</creatorcontrib><creatorcontrib>Wei, Xu</creatorcontrib><creatorcontrib>Zhan, Jia-Wen</creatorcontrib><creatorcontrib>Zhu, Liguo</creatorcontrib><creatorcontrib>Feng, Minshan</creatorcontrib><creatorcontrib>Xunlu, Yin</creatorcontrib><creatorcontrib>He, Yin</creatorcontrib><title>Integrative Bioinformatics Analysis Reveals Potential Gene Biomarkers and Analysis of Function in Human Degenerative Disc Annulus Fibrosus Cells</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Low back pain is a major cause of disability worldwide. Although numerous potential biomarkers for the early diagnosis or treatment of intervertebral disc degeneration (IDD) have been identified subsequent to the development of molecular biology technologies, the mechanisms of IDD remain unknown. Published studies found the unbalance of anabolism and catabolism of annulus fibrosus (AF) played an important role in it. The present study was aimed to identify the potential targets and signaling pathways of IDD, through the combined analysis of differential expression and based on the Gene Expression Omnibus (GEO) dataset from NCBI. PPI Networks Analysis indicated that MMP2 and AGE-RAGE signaling pathway and estrogen signaling pathway may play important roles in initiation and development of IDD. This study forecasted the pathogenesis molecular mechanism of IDD and the potential prognostic and diagnostic biomarkers, but we need to make further molecular biological experiments to confirm our assumptions.</description><subject>Annuli</subject><subject>Annulus Fibrosus - metabolism</subject><subject>Annulus Fibrosus - pathology</subject><subject>Antigens, Neoplasm - genetics</subject><subject>Arthritis</subject><subject>Back pain</subject><subject>Backache</subject><subject>Bioinformatics</subject><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>Biomechanics</subject><subject>Biosynthesis</subject><subject>Care and treatment</subject><subject>Catabolism</subject><subject>Cell adhesion & migration</subject><subject>Computational Biology</subject><subject>Cytochrome</subject><subject>Degeneration</subject><subject>Diagnostic systems</subject><subject>Estrogen</subject><subject>Estrogens</subject><subject>Gelatinase A</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation</subject><subject>Humans</subject><subject>Influenza</subject><subject>Intervertebral Disc - physiopathology</subject><subject>Intervertebral Disc Degeneration - diagnosis</subject><subject>Intervertebral Disc Degeneration - genetics</subject><subject>Intervertebral Disc Degeneration - pathology</subject><subject>Intervertebral discs</subject><subject>Joint surgery</subject><subject>Low back pain</subject><subject>Matrix Metalloproteinase 2 - genetics</subject><subject>Metabolism</subject><subject>Mitogen-Activated Protein Kinases - genetics</subject><subject>Molecular biology</subject><subject>Pain</subject><subject>Pathogenesis</subject><subject>Polymorphism</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Signal transduction</subject><subject>Signaling</subject><subject>Target recognition</subject><issn>2314-6133</issn><issn>2314-6141</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkk1v1DAQhiMEolXpjTOyxAUJlnpsJ7EvSMuWbStVAiE4W44z2bpk7dZOFvVf8JNx2GUXOOGLv555xzN-i-I50LcAZXnGKKgzJRVltXpUHDMOYlaBgMf7NedHxWlKtzQPCRVV1dPiiFMFJa_q4-LHlR9wFc3gNkjeu-B8F-I6b20ic2_6h-QS-YwbNH0in8KAfnCmJxfof-FrE79hTMT49oCHjixHbwcXPHGeXI5r48k5rnLMLtG5SzbzfuzHRJauiSHlxQL7Pj0rnnQ5F57u5pPi6_LDl8Xl7PrjxdVifj2zQqlhBry1jNWsQ9OZkrGWoyht00poLadVK6jtuOGtrMCikmhlU3KwyjY5ELngJ8W7re7d2Kwxn_khml7fRZdretDBOP33jXc3ehU2uhJUUTEJvNoJxHA_Yhr0OleVSzAew5g0AyXLGoTkGX35D3obxpjbNVGy5rVkUB2olelRTx-R89pJVM8rJgTUJZ2oN1vK5qaliN3-yUD15Ak9eULvPJHxF3-WuYd_OyADr7fAjfOt-e7-Uw4zg5050MAyIvlPk7_Klw</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Tao, Han</creator><creator>Xuepeng, Li</creator><creator>Long, Liang</creator><creator>Wang, Shangquan</creator><creator>Jie, Yu</creator><creator>Wei, Xu</creator><creator>Zhan, Jia-Wen</creator><creator>Zhu, Liguo</creator><creator>Feng, Minshan</creator><creator>Xunlu, Yin</creator><creator>He, Yin</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1130-3085</orcidid><orcidid>https://orcid.org/0000-0001-7193-8547</orcidid><orcidid>https://orcid.org/0000-0002-3388-4215</orcidid><orcidid>https://orcid.org/0000-0003-1748-418X</orcidid><orcidid>https://orcid.org/0000-0002-5845-1125</orcidid><orcidid>https://orcid.org/0000-0001-6723-9604</orcidid></search><sort><creationdate>20190101</creationdate><title>Integrative Bioinformatics Analysis Reveals Potential Gene Biomarkers and Analysis of Function in Human Degenerative Disc Annulus Fibrosus Cells</title><author>Tao, Han ; Xuepeng, Li ; Long, Liang ; Wang, Shangquan ; Jie, Yu ; Wei, Xu ; Zhan, Jia-Wen ; Zhu, Liguo ; Feng, Minshan ; Xunlu, Yin ; He, Yin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-13dc2272feafa522d3e45cbd81dc306d40cf3a3d861ce98ec8b531c9cb3dce343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Annuli</topic><topic>Annulus Fibrosus - metabolism</topic><topic>Annulus Fibrosus - pathology</topic><topic>Antigens, Neoplasm - genetics</topic><topic>Arthritis</topic><topic>Back pain</topic><topic>Backache</topic><topic>Bioinformatics</topic><topic>Biological markers</topic><topic>Biomarkers</topic><topic>Biomarkers - metabolism</topic><topic>Biomechanics</topic><topic>Biosynthesis</topic><topic>Care and treatment</topic><topic>Catabolism</topic><topic>Cell adhesion & migration</topic><topic>Computational Biology</topic><topic>Cytochrome</topic><topic>Degeneration</topic><topic>Diagnostic systems</topic><topic>Estrogen</topic><topic>Estrogens</topic><topic>Gelatinase A</topic><topic>Gene expression</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation</topic><topic>Humans</topic><topic>Influenza</topic><topic>Intervertebral Disc - physiopathology</topic><topic>Intervertebral Disc Degeneration - diagnosis</topic><topic>Intervertebral Disc Degeneration - genetics</topic><topic>Intervertebral Disc Degeneration - pathology</topic><topic>Intervertebral discs</topic><topic>Joint surgery</topic><topic>Low back pain</topic><topic>Matrix Metalloproteinase 2 - genetics</topic><topic>Metabolism</topic><topic>Mitogen-Activated Protein Kinases - genetics</topic><topic>Molecular biology</topic><topic>Pain</topic><topic>Pathogenesis</topic><topic>Polymorphism</topic><topic>Prognosis</topic><topic>Proteins</topic><topic>Signal transduction</topic><topic>Signaling</topic><topic>Target recognition</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tao, Han</creatorcontrib><creatorcontrib>Xuepeng, Li</creatorcontrib><creatorcontrib>Long, Liang</creatorcontrib><creatorcontrib>Wang, Shangquan</creatorcontrib><creatorcontrib>Jie, Yu</creatorcontrib><creatorcontrib>Wei, Xu</creatorcontrib><creatorcontrib>Zhan, Jia-Wen</creatorcontrib><creatorcontrib>Zhu, Liguo</creatorcontrib><creatorcontrib>Feng, Minshan</creatorcontrib><creatorcontrib>Xunlu, Yin</creatorcontrib><creatorcontrib>He, Yin</creatorcontrib><collection>الدوريات العلمية والإحصائية - 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Although numerous potential biomarkers for the early diagnosis or treatment of intervertebral disc degeneration (IDD) have been identified subsequent to the development of molecular biology technologies, the mechanisms of IDD remain unknown. Published studies found the unbalance of anabolism and catabolism of annulus fibrosus (AF) played an important role in it. The present study was aimed to identify the potential targets and signaling pathways of IDD, through the combined analysis of differential expression and based on the Gene Expression Omnibus (GEO) dataset from NCBI. PPI Networks Analysis indicated that MMP2 and AGE-RAGE signaling pathway and estrogen signaling pathway may play important roles in initiation and development of IDD. This study forecasted the pathogenesis molecular mechanism of IDD and the potential prognostic and diagnostic biomarkers, but we need to make further molecular biological experiments to confirm our assumptions.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>30915367</pmid><doi>10.1155/2019/9890279</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-1130-3085</orcidid><orcidid>https://orcid.org/0000-0001-7193-8547</orcidid><orcidid>https://orcid.org/0000-0002-3388-4215</orcidid><orcidid>https://orcid.org/0000-0003-1748-418X</orcidid><orcidid>https://orcid.org/0000-0002-5845-1125</orcidid><orcidid>https://orcid.org/0000-0001-6723-9604</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Annuli Annulus Fibrosus - metabolism Annulus Fibrosus - pathology Antigens, Neoplasm - genetics Arthritis Back pain Backache Bioinformatics Biological markers Biomarkers Biomarkers - metabolism Biomechanics Biosynthesis Care and treatment Catabolism Cell adhesion & migration Computational Biology Cytochrome Degeneration Diagnostic systems Estrogen Estrogens Gelatinase A Gene expression Gene Expression Profiling Gene Expression Regulation Humans Influenza Intervertebral Disc - physiopathology Intervertebral Disc Degeneration - diagnosis Intervertebral Disc Degeneration - genetics Intervertebral Disc Degeneration - pathology Intervertebral discs Joint surgery Low back pain Matrix Metalloproteinase 2 - genetics Metabolism Mitogen-Activated Protein Kinases - genetics Molecular biology Pain Pathogenesis Polymorphism Prognosis Proteins Signal transduction Signaling Target recognition |
| title | Integrative Bioinformatics Analysis Reveals Potential Gene Biomarkers and Analysis of Function in Human Degenerative Disc Annulus Fibrosus Cells |
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