DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs in Vitro and in Vivo

Chemogenetic tools such as designer receptors exclusively activated by designer drugs (DREADDs) are routinely used to modulate neuronal and non-neuronal signaling and activity in a relatively noninvasive manner. The first generation of DREADDs were templated from the human muscarinic acetylcholine r...

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Veröffentlicht in:ACS pharmacology & translational science 2018-09, Vol.1 (1), p.61-72
Hauptverfasser: Thompson, Karen J, Khajehali, Elham, Bradley, Sophie J, Navarrete, Jovana S, Huang, Xi Ping, Slocum, Samuel, Jin, Jian, Liu, Jing, Xiong, Yan, Olsen, Reid H. J, Diberto, Jeffrey F, Boyt, Kristen M, Pina, Melanie M, Pati, Dipanwita, Molloy, Colin, Bundgaard, Christoffer, Sexton, Patrick M, Kash, Thomas L, Krashes, Michael J, Christopoulos, Arthur, Roth, Bryan L, Tobin, Andrew B
Format: Artikel
Sprache:eng
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