Coupling of Zinc-Binding and Secondary Structure in Non-Fibrillar Aβ40 Peptide Oligomerization

Non-fibrillar neurotoxic amyloid β (Aβ) oligomer structures are typically rich in β-sheets, which could be promoted by metal ions like Zn 2+ . Here, using molecular dynamics (MD) simulations, we systematically examined combinations of Aβ40 peptide conformations and Zn 2+ binding modes to probe the e...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of chemical information and modeling 2015-06, Vol.55 (6), p.1218-1230
Hauptverfasser:	Xu, Liang, Shan, Shengsheng, Chen, Yonggang, Wang, Xiaojuan, Nussinov, Ruth, Ma, Buyong
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!