Cardiolipin-Dependent Mitophagy Guides Outcome after Traumatic Brain Injury

Mitochondrial energy production is essential for normal brain function. Traumatic brain injury (TBI) increases brain energy demands, results in the activation of mitochondrial respiration, associated with enhanced generation of reactive oxygen species. This chain of events triggers neuronal apoptosi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of neuroscience 2019-03, Vol.39 (10), p.1930-1943
Hauptverfasser:	Chao, Honglu, Lin, Chao, Zuo, Qiang, Liu, Yinlong, Xiao, Mengqing, Xu, Xiupeng, Li, Zheng, Bao, Zhongyuan, Chen, Huimei, You, Yongping, Kochanek, Patrick M, Yin, Huiyong, Liu, Ning, Kagan, Valerian E, Bayır, Hülya, Ji, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - physiology Brain Brain - metabolism Brain - ultrastructure Brain Injuries, Traumatic - metabolism Brain Injuries, Traumatic - pathology Cardiolipin Cardiolipins - metabolism Damage Electron transport Energy Head injuries Humans Male Mitochondria Mitochondrial Membranes - metabolism Mitophagy Mitophagy - physiology Neurons - metabolism Neurons - ultrastructure Neuroprotection Oxidation Phospholipids Rats, Sprague-Dawley Reactive oxygen species Signal Transduction Translocation Traumatic brain injury
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!