Intratumoural Heterogeneity Underlies Distinct Therapy Responses and Treatment Resistance in Glioblastoma

Glioblastomas are the most common and lethal neoplasms of the central nervous system. Neighbouring glioma cells maintain extreme degrees of genetic and phenotypic variation that form intratumoural heterogeneity. This genetic diversity allows the most adaptive tumour clones to develop treatment resis...

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Veröffentlicht in:	Cancers 2019-02, Vol.11 (2), p.190
Hauptverfasser:	Akgül, Seçkin, Patch, Ann-Marie, D'Souza, Rochelle C J, Mukhopadhyay, Pamela, Nones, Katia, Kempe, Sarah, Kazakoff, Stephen H, Jeffree, Rosalind L, Stringer, Brett W, Pearson, John V, Waddell, Nicola, Day, Bryan W
Format:	Artikel
Sprache:	eng
Schlagworte:	Central nervous system Chemotherapy Cloning CpG islands Cytology Disease resistance DNA methylation Genes Genetic diversity Genomes Genomics Glioblastoma Glioma cells Growth rate Ionizing radiation Metastases Mutation Neoplasia Phenotypic variations Radiation therapy Single-nucleotide polymorphism Temozolomide Therapeutic applications Tumors
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