Peroxisomes can oxidize medium‐ and long‐chain fatty acids through a pathway involving ABCD3 and HSD17B4

ABSTRACT Peroxisomes are essential organelles for the specialized oxidation of a wide variety of fatty acids, but they are also able to degrade fatty acids that are typically handled by mitochondria. Using a combination of pharmacological inhibition and clustered regularly interspaced short palindro...

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Veröffentlicht in:	The FASEB journal 2019-03, Vol.33 (3), p.4355-4364
Hauptverfasser:	Violante, Sara, Achetib, Nihad, Roermund, Carlo W. T., Hagen, Jacob, Dodatko, Tetyana, Vaz, Frédéric M., Waterham, Hans R., Chen, Hongjie, Baes, Myriam, Yu, Chunli, Argmann, Carmen A., Houten, Sander M.
Format:	Artikel
Sprache:	eng
Schlagworte:	acylcarnitine Animals ATP-Binding Cassette Transporters - deficiency ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - physiology Carnitine - analogs & derivatives Carnitine - metabolism Carnitine O-Palmitoyltransferase - antagonists & inhibitors Carnitine O-Palmitoyltransferase - deficiency Carnitine O-Palmitoyltransferase - physiology CPT2 deficiency CRISPR-Cas Systems fatty acid oxidation Fatty Acids - metabolism HEK293 Cells Humans Lauric Acids - metabolism Membrane Proteins - metabolism Mice Mice, Knockout mitochondria Mitochondria - enzymology organellar crosstalk Oxidation-Reduction Palmitic Acid - metabolism Peroxisomal Bifunctional Enzyme - deficiency Peroxisomal Multifunctional Protein-2 - deficiency Peroxisomal Multifunctional Protein-2 - genetics Peroxisomal Multifunctional Protein-2 - physiology Peroxisomes - enzymology Recombinant Proteins - metabolism
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