Proproliferative function of adaptor protein GRB10 in prostate carcinoma

ABSTRACT Growth factor receptor‐binding protein 10 (GRB10) is a well‐known adaptor protein and a recently identified substrate of the mammalian target of rapamycin (mTOR). Depletion of GRB10 increases insulin sensitivity and overexpression suppresses PI3K/Akt signaling. Because the major reason for...

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Veröffentlicht in:	The FASEB journal 2019-03, Vol.33 (3), p.3198-3211
Hauptverfasser:	Khan, Mohammad Imran, Johani, Ahmed Al, Hamid, Abid, Ateeq, Bushra, Manzar, Nishat, Adhami, Vaqar Mustafa, Lall, Rahul K., Rath, Suvasmita, Sechi, Mario, Siddiqui, Imtiaz Ahmad, Choudhry, Hani, Zamzami, Mazin A., Havighurst, Thomas C., Huang, Wei, Ntambi, James M., Mukhtar, Hasan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinogens - antagonists & inhibitors Carcinogens - metabolism Cell Line, Tumor Cell Proliferation - genetics Cell Proliferation - physiology Fibroblasts - cytology Fibroblasts - metabolism Gene Knockdown Techniques GRB10 GRB10 Adaptor Protein - antagonists & inhibitors GRB10 Adaptor Protein - genetics GRB10 Adaptor Protein - metabolism Humans Male Mechanistic Target of Rapamycin Complex 1 - metabolism Mice Models, Biological mTOR Phosphatidylinositol 3-Kinases - metabolism PI3K Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology PTEN PTEN Phosphohydrolase - deficiency PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism RNA, Messenger RTKs Signal Transduction
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