TREX1 is expressed by microglia in normal human brain and increases in regions affected by ischemia

Background Mutations in the three‐prime repair exonuclease 1 (TREX1) gene have been associated with neurological diseases, including Retinal Vasculopathy with Cerebral Leukoencephalopathy (RVCL). However, the endogenous expression of TREX1 in human brain has not been studied. Methods We produced a r...

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Veröffentlicht in:	Brain pathology (Zurich, Switzerland) Switzerland), 2018-11, Vol.28 (6), p.806-821
Hauptverfasser:	Kothari, Parul H., Kolar, Grant R., Jen, Joanna C., Hajj‐Ali, Rula, Bertram, Paula, Schmidt, Robert E., Atkinson, John P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Antibodies - metabolism Brain Brain - metabolism Brain - pathology brain ischemia Brain Ischemia - metabolism Brain Ischemia - pathology Central nervous system Cerebral cortex DNase1 Exodeoxyribonucleases - genetics Exodeoxyribonucleases - metabolism Exodeoxyribonucleases - physiology Exonuclease Female Frameshift Mutation HEK293 Cells HeLa Cells Hereditary Central Nervous System Demyelinating Diseases - genetics Hereditary Central Nervous System Demyelinating Diseases - pathology Homeostasis Homeostasis - physiology Humans Ischemia Lesions Leukoencephalopathy Lysates Macrophages Macrophages - metabolism Male Microglia Microglia - metabolism Microvasculature Middle Aged Mutation Neurological diseases Paraffin Paraffins Patients Phosphoproteins - genetics Phosphoproteins - metabolism Phosphoproteins - physiology Polyclonal antibodies Rabbits - immunology Retina Retinal Diseases - genetics Retinal Diseases - pathology Staining Stroke Substantia alba Substantia grisea TREX1 Vascular diseases Vascular Diseases - genetics Vascular Diseases - pathology vasculopathy Western blotting
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