Assessing Treatment Response of Glioblastoma to an HDAC Inhibitor Using Whole-Brain Spectroscopic MRI

Histone deacetylases regulate a wide variety of cellular functions and have been implicated in redifferentiation of various tumors. Histone deacetylase inhibitors (HDACi) are potential pharmacologic agents to improve outcomes for patients with gliomas. We assessed the therapeutic efficacy of belinos...

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Veröffentlicht in:	Tomography (Ann Arbor) 2019-03, Vol.5 (1), p.53-60
Hauptverfasser:	Gurbani, Saumya S, Yoon, Younghyoun, Weinberg, Brent D, Salgado, Eric, Press, Robert H, Cordova, J Scott, Ramesh, Karthik K, Liang, Zhongxing, Velazquez Vega, Jose, Voloschin, Alfredo, Olson, Jeffrey J, Schreibmann, Eduard, Shim, Hyunsuk, Shu, Hui-Kuo G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Antidepressive Agents - administration & dosage Antidepressive Agents - therapeutic use Antineoplastic Agents - administration & dosage Antineoplastic Agents - therapeutic use Behavior, Animal - drug effects Brain Neoplasms - diagnostic imaging Brain Neoplasms - drug therapy Brain Neoplasms - pathology Brain Neoplasms - psychology Depression - drug therapy Depression - etiology Dose-Response Relationship, Drug Female Glioblastoma - diagnostic imaging Glioblastoma - drug therapy Glioblastoma - pathology Glioblastoma - psychology Histone Deacetylase Inhibitors - administration & dosage Histone Deacetylase Inhibitors - therapeutic use Humans Hydroxamic Acids - administration & dosage Hydroxamic Acids - therapeutic use Kaplan-Meier Estimate Magnetic Resonance Imaging - methods Male Middle Aged Neoplasm Transplantation Pilot Projects Rats, Inbred F344 Sulfonamides - administration & dosage Sulfonamides - therapeutic use Treatment Outcome Tumor Cells, Cultured
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