Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis

Identification of cell-surface markers specific to human pancreatic β cells would allow in vivo analysis and imaging. Here we introduce a biomarker, ectonucleoside triphosphate diphosphohydrolase-3 (NTPDase3), that is expressed on the cell surface of essentially all adult human β cells, including th...

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Veröffentlicht in:	Cell metabolism 2019-03, Vol.29 (3), p.745-754.e4
Hauptverfasser:	Saunders, Diane C., Brissova, Marcela, Phillips, Neil, Shrestha, Shristi, Walker, John T., Aramandla, Radhika, Poffenberger, Greg, Flaherty, David K., Weller, Kevin P., Pelletier, Julie, Cooper, Tracy, Goff, Matt T., Virostko, John, Shostak, Alena, Dean, E. Danielle, Greiner, Dale L., Shultz, Leonard D., Prasad, Nripesh, Levy, Shawn E., Carnahan, Robert H., Dai, Chunhua, Sévigny, Jean, Powers, Alvin C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism Adult Animals Biomarkers - metabolism Cells, Cultured development diabetes Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 2 - metabolism glucagon Humans imaging insulin Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - pathology islet Islets of Langerhans - metabolism Islets of Langerhans - pathology Male Membrane Proteins - metabolism Mice Mice, Inbred NOD pancreas Pancreas - metabolism Pancreas - pathology Young Adult
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