Cooperative Changes in Solvent Exposure Identify Cryptic Pockets, Switches, and Allosteric Coupling

Proteins are dynamic molecules that undergo conformational changes to a broad spectrum of different excited states. Unfortunately, the small populations of these states make it difficult to determine their structures or functional implications. Computer simulations are an increasingly powerful means...

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Veröffentlicht in:	Biophysical journal 2019-03, Vol.116 (5), p.818-830
Hauptverfasser:	Porter, Justin R., Moeder, Katelyn E., Sibbald, Carrie A., Zimmerman, Maxwell I., Hart, Kathryn M., Greenberg, Michael J., Bowman, Gregory R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Site beta-Lactamases - chemistry Cyclic AMP Receptor Protein - chemistry Escherichia coli Proteins - chemistry Models, Molecular Protein Conformation Proteins - chemistry Solvents - chemistry
Online-Zugang:	Volltext
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