Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation
Key events ranging from cell polarity to proliferation regulation to neuronal signaling rely on the assembly of multiprotein adhesion or signaling complexes at particular subcellular sites. Multidomain scaffolding proteins nucleate assembly and direct localization of these complexes, and the protein...
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| Veröffentlicht in: | The Journal of cell biology 2019-03, Vol.218 (3), p.742-756 |
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| container_title | The Journal of cell biology |
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| creator | Bonello, Teresa T Peifer, Mark |
| description | Key events ranging from cell polarity to proliferation regulation to neuronal signaling rely on the assembly of multiprotein adhesion or signaling complexes at particular subcellular sites. Multidomain scaffolding proteins nucleate assembly and direct localization of these complexes, and the protein Scribble and its relatives in the LAP protein family provide a paradigm for this. Scribble was originally identified because of its role in apical-basal polarity and epithelial integrity in
It is now clear that Scribble acts to assemble and position diverse multiprotein complexes in processes ranging from planar polarity to adhesion to oriented cell division to synaptogenesis. Here, we explore what we have learned about the mechanisms of action of Scribble in the context of its multiple known interacting partners and discuss how this knowledge opens new questions about the full range of Scribble protein partners and their structural and signaling roles. |
| doi_str_mv | 10.1083/jcb.201810103 |
| format | Article |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adhesion Animals Assembly Cell Adhesion - physiology Cell division Cell Polarity - physiology Cell Proliferation - physiology Drosophila melanogaster Drosophila Proteins - metabolism Fruit flies LAP protein Localization Membrane Proteins - metabolism Multiprotein Complexes - metabolism Polarity Proteins Reviews Scaffolding Signal Transduction - physiology Signaling Synaptogenesis |
| title | Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation |
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