Intraperitoneal injection of MSC-derived exosomes prevent experimental bronchopulmonary dysplasia
Mesenchymal stromal cell (MSC) derived exosomes mediate tissue protection and regeneration in many injuries and diseases by modulating cell protein production, protecting from apoptosis, inhibiting inflammation, and increasing angiogenesis. In the present study, daily intraperitoneal injection of MS...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2018-09, Vol.503 (4), p.2653-2658 |
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| creator | Braun, Rudolf K. Chetty, Chandramu Balasubramaniam, Vivek Centanni, Ryan Haraldsdottir, Kristin Hematti, Peiman Eldridge, Marlowe W. |
| description | Mesenchymal stromal cell (MSC) derived exosomes mediate tissue protection and regeneration in many injuries and diseases by modulating cell protein production, protecting from apoptosis, inhibiting inflammation, and increasing angiogenesis. In the present study, daily intraperitoneal injection of MSC-derived exosomes protected alveolarization and angiogenesis in a newborn rat model of bronchopulmonary dysplasia (BPD) induced by 14 days of neonatal hyperoxia exposure (85% O2). Exosome treatment during hyperoxia prevented disruption of alveolar growth, increased small blood vessel number, and inhibited right heart hypertrophy at P14, P21, and P56. In vitro, exosomes significantly increased tube-like network formation by HUVEC, in part through a VEGF mediated mechanism. In summary, daily intraperitoneal injection of exosomes increased blood vessel number and size in the lung through pro-angiogenic mechanisms. MSC-derived exosomes therefore have both anti-inflammatory and pro-angiogenic mechanism to protect the lung from hyperoxia induced lung and heart disease associated with BPD. |
| doi_str_mv | 10.1016/j.bbrc.2018.08.019 |
| format | Article |
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In the present study, daily intraperitoneal injection of MSC-derived exosomes protected alveolarization and angiogenesis in a newborn rat model of bronchopulmonary dysplasia (BPD) induced by 14 days of neonatal hyperoxia exposure (85% O2). Exosome treatment during hyperoxia prevented disruption of alveolar growth, increased small blood vessel number, and inhibited right heart hypertrophy at P14, P21, and P56. In vitro, exosomes significantly increased tube-like network formation by HUVEC, in part through a VEGF mediated mechanism. In summary, daily intraperitoneal injection of exosomes increased blood vessel number and size in the lung through pro-angiogenic mechanisms. MSC-derived exosomes therefore have both anti-inflammatory and pro-angiogenic mechanism to protect the lung from hyperoxia induced lung and heart disease associated with BPD.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2018.08.019</identifier><identifier>PMID: 30093115</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>60 APPLIED LIFE SCIENCES ; angiogenesis ; animal models ; Animals ; Animals, Newborn ; apoptosis ; BLOOD VESSELS ; Bone Marrow Cells - chemistry ; Bone Marrow Cells - cytology ; Bronchopulmonary dysplasia ; Bronchopulmonary Dysplasia - genetics ; Bronchopulmonary Dysplasia - metabolism ; Bronchopulmonary Dysplasia - pathology ; Bronchopulmonary Dysplasia - prevention & control ; Cardiomegaly - genetics ; Cardiomegaly - metabolism ; Cardiomegaly - pathology ; Cardiomegaly - prevention & control ; CARDIOVASCULAR DISEASES ; Chronic lung disease ; Disease Models, Animal ; Exosomes ; Exosomes - physiology ; Exosomes - transplantation ; Female ; Gene Expression Regulation ; heart ; heart diseases ; hyperoxia ; Hyperoxia - genetics ; Hyperoxia - metabolism ; Hyperoxia - pathology ; Hyperoxia - prevention & control ; hypertrophy ; inflammation ; Injections, Intraperitoneal ; intraperitoneal injection ; Lung - blood supply ; Lung - metabolism ; Lung - pathology ; Lung prematurity ; LUNGS ; Mesenchymal Stem Cells - chemistry ; Mesenchymal Stem Cells - cytology ; Mesenchymal stromal cells ; neonates ; Neovascularization, Physiologic - genetics ; oxygen ; Oxygen - toxicity ; Pregnancy ; Primary Cell Culture ; protein synthesis ; RATS ; Rats, Sprague-Dawley ; Vascular Endothelial Growth Factor A - agonists ; Vascular Endothelial Growth Factor A - genetics ; Vascular Endothelial Growth Factor A - metabolism ; vascular endothelial growth factors</subject><ispartof>Biochemical and biophysical research communications, 2018-09, Vol.503 (4), p.2653-2658</ispartof><rights>2018</rights><rights>Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c631t-8c3e7c68f64d9a6b6aff704f0f0238f76df84dd242927571dff37dab3a6562ee3</citedby><cites>FETCH-LOGICAL-c631t-8c3e7c68f64d9a6b6aff704f0f0238f76df84dd242927571dff37dab3a6562ee3</cites><orcidid>0000-0002-1778-9613</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006291X18316930$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27903,27904,65308</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30093115$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/23103619$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Braun, Rudolf K.</creatorcontrib><creatorcontrib>Chetty, Chandramu</creatorcontrib><creatorcontrib>Balasubramaniam, Vivek</creatorcontrib><creatorcontrib>Centanni, Ryan</creatorcontrib><creatorcontrib>Haraldsdottir, Kristin</creatorcontrib><creatorcontrib>Hematti, Peiman</creatorcontrib><creatorcontrib>Eldridge, Marlowe W.</creatorcontrib><title>Intraperitoneal injection of MSC-derived exosomes prevent experimental bronchopulmonary dysplasia</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Mesenchymal stromal cell (MSC) derived exosomes mediate tissue protection and regeneration in many injuries and diseases by modulating cell protein production, protecting from apoptosis, inhibiting inflammation, and increasing angiogenesis. In the present study, daily intraperitoneal injection of MSC-derived exosomes protected alveolarization and angiogenesis in a newborn rat model of bronchopulmonary dysplasia (BPD) induced by 14 days of neonatal hyperoxia exposure (85% O2). Exosome treatment during hyperoxia prevented disruption of alveolar growth, increased small blood vessel number, and inhibited right heart hypertrophy at P14, P21, and P56. In vitro, exosomes significantly increased tube-like network formation by HUVEC, in part through a VEGF mediated mechanism. In summary, daily intraperitoneal injection of exosomes increased blood vessel number and size in the lung through pro-angiogenic mechanisms. MSC-derived exosomes therefore have both anti-inflammatory and pro-angiogenic mechanism to protect the lung from hyperoxia induced lung and heart disease associated with BPD.</description><subject>60 APPLIED LIFE SCIENCES</subject><subject>angiogenesis</subject><subject>animal models</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>apoptosis</subject><subject>BLOOD VESSELS</subject><subject>Bone Marrow Cells - chemistry</subject><subject>Bone Marrow Cells - cytology</subject><subject>Bronchopulmonary dysplasia</subject><subject>Bronchopulmonary Dysplasia - genetics</subject><subject>Bronchopulmonary Dysplasia - metabolism</subject><subject>Bronchopulmonary Dysplasia - pathology</subject><subject>Bronchopulmonary Dysplasia - prevention & control</subject><subject>Cardiomegaly - genetics</subject><subject>Cardiomegaly - metabolism</subject><subject>Cardiomegaly - pathology</subject><subject>Cardiomegaly - prevention & control</subject><subject>CARDIOVASCULAR DISEASES</subject><subject>Chronic lung disease</subject><subject>Disease Models, Animal</subject><subject>Exosomes</subject><subject>Exosomes - physiology</subject><subject>Exosomes - transplantation</subject><subject>Female</subject><subject>Gene Expression Regulation</subject><subject>heart</subject><subject>heart diseases</subject><subject>hyperoxia</subject><subject>Hyperoxia - genetics</subject><subject>Hyperoxia - metabolism</subject><subject>Hyperoxia - pathology</subject><subject>Hyperoxia - prevention & control</subject><subject>hypertrophy</subject><subject>inflammation</subject><subject>Injections, Intraperitoneal</subject><subject>intraperitoneal injection</subject><subject>Lung - blood supply</subject><subject>Lung - metabolism</subject><subject>Lung - pathology</subject><subject>Lung prematurity</subject><subject>LUNGS</subject><subject>Mesenchymal Stem Cells - chemistry</subject><subject>Mesenchymal Stem Cells - cytology</subject><subject>Mesenchymal stromal cells</subject><subject>neonates</subject><subject>Neovascularization, Physiologic - genetics</subject><subject>oxygen</subject><subject>Oxygen - toxicity</subject><subject>Pregnancy</subject><subject>Primary Cell Culture</subject><subject>protein synthesis</subject><subject>RATS</subject><subject>Rats, Sprague-Dawley</subject><subject>Vascular Endothelial Growth Factor A - agonists</subject><subject>Vascular Endothelial Growth Factor A - genetics</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><subject>vascular endothelial growth factors</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUcGKFDEQbURxZ1d_wIM0ePHSYyXpTicgwjLourDiQQVvIZ1UnAw9SZv0DO7fm3bWRS8KBQmpVy_v1auqZwTWBAh_tVsPQzJrCkSsoRSRD6oVAQkNJdA-rFYAwBsqydez6jznHQAhLZePqzMGIBkh3arS12FOesLk5xhQj7UPOzSzj6GOrv7wadPY0juirfFHzHGPuZ4SHjHM5WEZ25drGRtSDGYbp8O4j0Gn29re5mnU2esn1SOnx4xP786L6su7t58375ubj1fXm8ubxnBG5kYYhr3hwvHWSs0Hrp3roXXggDLhem6daK2lLZW073pinWO91QPTvOMUkV1Ub06802HYozW4GBvVVCQWPSpqr_7uBL9V3-JRcSaFZLQQvDgRxDx7lY2f0WxNDKHsQ1FGgHEiC-rl3Tcpfj9gntXeZ4PjqAPGQ1aUMCI6Iaj4PxRE30nS9W2B0hPUpJhzQnevm4BawlY7tYStlrAVlPol5fmfju9HfqdbAK9PACx7P3pMiysMBq1Piykb_b_4fwLFJ732</recordid><startdate>20180918</startdate><enddate>20180918</enddate><creator>Braun, Rudolf K.</creator><creator>Chetty, Chandramu</creator><creator>Balasubramaniam, Vivek</creator><creator>Centanni, Ryan</creator><creator>Haraldsdottir, Kristin</creator><creator>Hematti, Peiman</creator><creator>Eldridge, Marlowe W.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>OTOTI</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1778-9613</orcidid></search><sort><creationdate>20180918</creationdate><title>Intraperitoneal injection of MSC-derived exosomes prevent experimental bronchopulmonary dysplasia</title><author>Braun, Rudolf K. ; Chetty, Chandramu ; Balasubramaniam, Vivek ; Centanni, Ryan ; Haraldsdottir, Kristin ; Hematti, Peiman ; Eldridge, Marlowe W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c631t-8c3e7c68f64d9a6b6aff704f0f0238f76df84dd242927571dff37dab3a6562ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>60 APPLIED LIFE SCIENCES</topic><topic>angiogenesis</topic><topic>animal models</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>apoptosis</topic><topic>BLOOD VESSELS</topic><topic>Bone Marrow Cells - chemistry</topic><topic>Bone Marrow Cells - cytology</topic><topic>Bronchopulmonary dysplasia</topic><topic>Bronchopulmonary Dysplasia - genetics</topic><topic>Bronchopulmonary Dysplasia - metabolism</topic><topic>Bronchopulmonary Dysplasia - pathology</topic><topic>Bronchopulmonary Dysplasia - prevention & control</topic><topic>Cardiomegaly - genetics</topic><topic>Cardiomegaly - metabolism</topic><topic>Cardiomegaly - pathology</topic><topic>Cardiomegaly - prevention & control</topic><topic>CARDIOVASCULAR DISEASES</topic><topic>Chronic lung disease</topic><topic>Disease Models, Animal</topic><topic>Exosomes</topic><topic>Exosomes - physiology</topic><topic>Exosomes - transplantation</topic><topic>Female</topic><topic>Gene Expression Regulation</topic><topic>heart</topic><topic>heart diseases</topic><topic>hyperoxia</topic><topic>Hyperoxia - genetics</topic><topic>Hyperoxia - metabolism</topic><topic>Hyperoxia - pathology</topic><topic>Hyperoxia - prevention & control</topic><topic>hypertrophy</topic><topic>inflammation</topic><topic>Injections, Intraperitoneal</topic><topic>intraperitoneal injection</topic><topic>Lung - blood supply</topic><topic>Lung - metabolism</topic><topic>Lung - pathology</topic><topic>Lung prematurity</topic><topic>LUNGS</topic><topic>Mesenchymal Stem Cells - chemistry</topic><topic>Mesenchymal Stem Cells - cytology</topic><topic>Mesenchymal stromal cells</topic><topic>neonates</topic><topic>Neovascularization, Physiologic - genetics</topic><topic>oxygen</topic><topic>Oxygen - toxicity</topic><topic>Pregnancy</topic><topic>Primary Cell Culture</topic><topic>protein synthesis</topic><topic>RATS</topic><topic>Rats, Sprague-Dawley</topic><topic>Vascular Endothelial Growth Factor A - agonists</topic><topic>Vascular Endothelial Growth Factor A - genetics</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><topic>vascular endothelial growth factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Braun, Rudolf K.</creatorcontrib><creatorcontrib>Chetty, Chandramu</creatorcontrib><creatorcontrib>Balasubramaniam, Vivek</creatorcontrib><creatorcontrib>Centanni, Ryan</creatorcontrib><creatorcontrib>Haraldsdottir, Kristin</creatorcontrib><creatorcontrib>Hematti, Peiman</creatorcontrib><creatorcontrib>Eldridge, Marlowe W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Braun, Rudolf K.</au><au>Chetty, Chandramu</au><au>Balasubramaniam, Vivek</au><au>Centanni, Ryan</au><au>Haraldsdottir, Kristin</au><au>Hematti, Peiman</au><au>Eldridge, Marlowe W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intraperitoneal injection of MSC-derived exosomes prevent experimental bronchopulmonary dysplasia</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2018-09-18</date><risdate>2018</risdate><volume>503</volume><issue>4</issue><spage>2653</spage><epage>2658</epage><pages>2653-2658</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Mesenchymal stromal cell (MSC) derived exosomes mediate tissue protection and regeneration in many injuries and diseases by modulating cell protein production, protecting from apoptosis, inhibiting inflammation, and increasing angiogenesis. In the present study, daily intraperitoneal injection of MSC-derived exosomes protected alveolarization and angiogenesis in a newborn rat model of bronchopulmonary dysplasia (BPD) induced by 14 days of neonatal hyperoxia exposure (85% O2). Exosome treatment during hyperoxia prevented disruption of alveolar growth, increased small blood vessel number, and inhibited right heart hypertrophy at P14, P21, and P56. In vitro, exosomes significantly increased tube-like network formation by HUVEC, in part through a VEGF mediated mechanism. In summary, daily intraperitoneal injection of exosomes increased blood vessel number and size in the lung through pro-angiogenic mechanisms. MSC-derived exosomes therefore have both anti-inflammatory and pro-angiogenic mechanism to protect the lung from hyperoxia induced lung and heart disease associated with BPD.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30093115</pmid><doi>10.1016/j.bbrc.2018.08.019</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-1778-9613</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 60 APPLIED LIFE SCIENCES angiogenesis animal models Animals Animals, Newborn apoptosis BLOOD VESSELS Bone Marrow Cells - chemistry Bone Marrow Cells - cytology Bronchopulmonary dysplasia Bronchopulmonary Dysplasia - genetics Bronchopulmonary Dysplasia - metabolism Bronchopulmonary Dysplasia - pathology Bronchopulmonary Dysplasia - prevention & control Cardiomegaly - genetics Cardiomegaly - metabolism Cardiomegaly - pathology Cardiomegaly - prevention & control CARDIOVASCULAR DISEASES Chronic lung disease Disease Models, Animal Exosomes Exosomes - physiology Exosomes - transplantation Female Gene Expression Regulation heart heart diseases hyperoxia Hyperoxia - genetics Hyperoxia - metabolism Hyperoxia - pathology Hyperoxia - prevention & control hypertrophy inflammation Injections, Intraperitoneal intraperitoneal injection Lung - blood supply Lung - metabolism Lung - pathology Lung prematurity LUNGS Mesenchymal Stem Cells - chemistry Mesenchymal Stem Cells - cytology Mesenchymal stromal cells neonates Neovascularization, Physiologic - genetics oxygen Oxygen - toxicity Pregnancy Primary Cell Culture protein synthesis RATS Rats, Sprague-Dawley Vascular Endothelial Growth Factor A - agonists Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism vascular endothelial growth factors |
| title | Intraperitoneal injection of MSC-derived exosomes prevent experimental bronchopulmonary dysplasia |
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