Antinociceptive Effects of the Antidepressant Phenelzine are Mediated by Context-Dependent Inhibition of Neuronal Responses in the Dorsal Horn

•PLZ inhibits second phase formalin nocifensive behaviors.•PLZ inhibits Glu-evoked Ca2+ responses.•PLZ exerts its effects through a 5-HT/5HT1AR pathway. The putative strong anti-nociceptive properties of the antidepressant phenelzine (PLZ) have not been widely explored as a treatment for pain. Antin...

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Veröffentlicht in:	Neuroscience 2018-07, Vol.383, p.205-215
Hauptverfasser:	Potter, Liam E., Doolen, Suzanne, Mifflin, Katherine, Tenorio, Gustavo, Baker, Glen, Taylor, Bradley K., Kerr, Bradley J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressive Agents - pharmacology calcium imaging dorsal horn Female formalin Hyperalgesia - metabolism MAOI Mice Mice, Inbred C57BL Neurons - drug effects Neurons - metabolism pain Pain - metabolism phenelzine Phenelzine - pharmacology Receptors, Serotonin, 5-HT1 - metabolism Serotonin - metabolism Spinal Cord Dorsal Horn - drug effects Spinal Cord Dorsal Horn - metabolism
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