Tricarboxylic acid cycle activity suppresses acetylation of mitochondrial proteins during early embryonic development in Caenorhabditis elegans

The tricarboxylic acid (TCA) cycle (or citric acid cycle) is responsible for the complete oxidation of acetyl-CoA and formation of intermediates required for ATP production and other anabolic pathways, such as amino acid synthesis. Here, we uncovered an additional mechanism that may help explain the...

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Veröffentlicht in:	The Journal of biological chemistry 2019-03, Vol.294 (9), p.3091-3099
Hauptverfasser:	Hada, Kazumasa, Hirota, Keiko, Inanobe, Ai, Kako, Koichiro, Miyata, Mai, Araoi, Sho, Matsumoto, Masaki, Ohta, Reiya, Arisawa, Mitsuhiro, Daitoku, Hiroaki, Hanada, Toshikatsu, Fukamizu, Akiyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	acetyl coenzyme A (acetyl-CoA) Acetylation Adenosine Triphosphate - metabolism Animals Aspartic Acid - metabolism Caenorhabditis elegans (C. elegans) Caenorhabditis elegans - cytology Caenorhabditis elegans - embryology Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Citrate (si)-Synthase - deficiency Citrate (si)-Synthase - genetics citrate synthase Citric Acid - metabolism Citric Acid Cycle deacetylase early embryogenesis Embryonic Development Glutamic Acid - metabolism Intracellular Space - metabolism Metabolism mitochondrial protein acetylation Mitochondrial Proteins - metabolism polyamine post-translational modification (PTM) sirtuin Time Factors tricarboxylic acid cycle (TCA cycle) (Krebs cycle)
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