HIV-Nef Protein Persists in the Lungs of Aviremic Patients with HIV and Induces Endothelial Cell Death

It remains a mystery why HIV-associated end-organ pathologies persist in the era of combined antiretroviral therapy (ART). One possible mechanism is the continued production of HIV-encoded proteins in latently HIV-infected T cells and macrophages. The proapoptotic protein HIV-Nef persists in the blo...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2019-03, Vol.60 (3), p.357-366
Hauptverfasser:	Chelvanambi, Sarvesh, Bogatcheva, Natalia V, Bednorz, Mariola, Agarwal, Stuti, Maier, Bernhard, Alves, Nathan J, Li, Wei, Syed, Farooq, Saber, Manal M, Dahl, Noelle, Lu, Hongyan, Day, Richard B, Smith, Patricia, Jolicoeur, Paul, Yu, Qigui, Dhillon, Navneet K, Weissmann, Norbert, Twigg Iii, Homer L, Clauss, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Animals Antiretroviral therapy Apoptosis Apoptosis - physiology Cell death Cell Death - physiology Cell Line Cell Line, Tumor Cells, Cultured Cigarettes Cytokines - metabolism Disease Drug therapy Emphysema Endothelial cells Endothelial Cells - metabolism Endothelial Cells - virology Endothelium - metabolism Endothelium - virology Gene expression HEK293 Cells HIV HIV Infections - metabolism HIV Infections - virology Human immunodeficiency virus Humans Infections Jurkat Cells Kidneys Leukocytes (mononuclear) Leukocytes, Mononuclear - metabolism Leukocytes, Mononuclear - virology Lung - metabolism Lung - virology Lungs Lymphocytes Lymphocytes T Macrophages Macrophages - metabolism Macrophages - virology Mice Microvasculature nef Gene Products, Human Immunodeficiency Virus - metabolism Nef protein Neoplasm Proteins - metabolism Original Research Peripheral blood mononuclear cells Polypeptides Proteins Pulmonary Emphysema - metabolism Pulmonary Emphysema - virology Pulmonary hypertension Respiration RNA-Binding Proteins - metabolism T-Lymphocytes - metabolism T-Lymphocytes - virology Vascular endothelial growth factor Viral infections
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