Anaphase-promoting complex/cyclosome regulates RdDM activity by degrading DMS3 in Arabidopsis

During RNA-directed DNA methylation (RdDM), the DDR complex, composed of DRD1, DMS3, and RDM1, is responsible for recruiting DNA polymerase V (Pol V) to silence transposable elements (TEs) in plants. However, how the DDR complex is regulated remains unexplored. Here, we show that the anaphase-promot...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-02, Vol.116 (9), p.3899-3908
Hauptverfasser:	Zhong, Songxiao, Xu, Yifeng, Yu, Chaoyi, Zhang, Xiaotuo, Li, Lei, Ge, Haoran, Ren, Guodong, Wang, Yingxiang, Ma, Jinbiao, Zheng, Yun, Zheng, Binglian
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaphase Anaphase-promoting complex Anaphase-Promoting Complex-Cyclosome - chemistry Anaphase-Promoting Complex-Cyclosome - genetics Arabidopsis - genetics Arabidopsis Proteins - chemistry Arabidopsis Proteins - genetics Assembly Biological Sciences Cell cycle Chromosomal Proteins, Non-Histone - chemistry Chromosomal Proteins, Non-Histone - genetics Degradation Deoxyribonucleic acid Discoidin Domain Receptors - chemistry Discoidin Domain Receptors - genetics DNA DNA methylation DNA Methylation - genetics DNA polymerase DNA Transposable Elements - genetics DNA-directed DNA polymerase DNA-Directed RNA Polymerases - chemistry DNA-Directed RNA Polymerases - genetics Dopamine D1 receptors Gel filtration Gene Expression Regulation, Plant Gene Silencing Multiprotein Complexes - chemistry Multiprotein Complexes - genetics PNAS Plus Proteins Ribonucleic acid RNA RNA, Plant - genetics RNA, Small Interfering - genetics
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