Cloning, function, and localization of human, canine, and Drosophila ZIP10 (SLC39A10), a Zn2+ transporter
Zinc (Zn 2+ ) is the second most abundant trace element, but is considered a micronutrient, as it is a cofactor for many enzymes and transcription factors. Whereas Zn 2+ deficiency can cause cognitive immune or metabolic dysfunction and infertility, excess Zn 2+ is nephrotoxic. As for other ions and...
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| Veröffentlicht in: | American journal of physiology. Renal physiology 2019-02, Vol.316 (2), p.F263-F273 |
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| creator | Landry, Greg M. Furrow, Eva Holmes, Heather L. Hirata, Taku Kato, Akira Williams, Paige Strohmaier, Käri Gallo, Chris J. R. Chang, Minhwang Pandey, Mukesh K. Jiang, Huailei Bansal, Aditya Franz, Marie-Christine Montalbetti, Nicolas Alexander, Mariam P. Cabrero, Pablo Dow, Julian A. T. DeGrado, Timothy R. Romero, Michael F. |
| description | Zinc (Zn
2+
) is the second most abundant trace element, but is considered a micronutrient, as it is a cofactor for many enzymes and transcription factors. Whereas Zn
2+
deficiency can cause cognitive immune or metabolic dysfunction and infertility, excess Zn
2+
is nephrotoxic. As for other ions and solutes, Zn
2+
is moved into and out of cells by specific membrane transporters: ZnT, Zip, and NRAMP/DMT proteins. ZIP10 is reported to be localized at the apical membrane of renal proximal tubules in rats, where it is believed to play a role in Zn
2+
import. Renal regulation of Zn
2+
is of particular interest in light of growing evidence that Zn
2+
may play a role in kidney stone formation. The objective of this study was to show that ZIP10 homologs transport Zn
2+
, as well as ZIP10, kidney localization across species. We cloned ZIP10 from dog, human, and
Drosophila
(
CG10006
), tested clones for Zn
2+
uptake in
Xenopus
oocytes and localized the protein in renal structures.
CG10006
, rather than
foi
(fear-of-intimacy,
CG6817
) is the primary ZIP10 homolog found in
Drosophila
Malpighian tubules. The ZIP10 antibody recognizes recombinant dog, human, and
Drosophila
ZIP10 proteins. Immunohistochemistry reveals that ZIP10 in higher mammals is found not only in the proximal tubule, but also in the collecting duct system. These ZIP10 proteins show Zn
2+
transport. Together, these studies reveal ZIP10 kidney localization, a role in renal Zn
2+
transport, and indicates that
CG10006
is a
Drosophila
homolog of ZIP10. |
| doi_str_mv | 10.1152/ajprenal.00573.2017 |
| format | Article |
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2+
) is the second most abundant trace element, but is considered a micronutrient, as it is a cofactor for many enzymes and transcription factors. Whereas Zn
2+
deficiency can cause cognitive immune or metabolic dysfunction and infertility, excess Zn
2+
is nephrotoxic. As for other ions and solutes, Zn
2+
is moved into and out of cells by specific membrane transporters: ZnT, Zip, and NRAMP/DMT proteins. ZIP10 is reported to be localized at the apical membrane of renal proximal tubules in rats, where it is believed to play a role in Zn
2+
import. Renal regulation of Zn
2+
is of particular interest in light of growing evidence that Zn
2+
may play a role in kidney stone formation. The objective of this study was to show that ZIP10 homologs transport Zn
2+
, as well as ZIP10, kidney localization across species. We cloned ZIP10 from dog, human, and
Drosophila
(
CG10006
), tested clones for Zn
2+
uptake in
Xenopus
oocytes and localized the protein in renal structures.
CG10006
, rather than
foi
(fear-of-intimacy,
CG6817
) is the primary ZIP10 homolog found in
Drosophila
Malpighian tubules. The ZIP10 antibody recognizes recombinant dog, human, and
Drosophila
ZIP10 proteins. Immunohistochemistry reveals that ZIP10 in higher mammals is found not only in the proximal tubule, but also in the collecting duct system. These ZIP10 proteins show Zn
2+
transport. Together, these studies reveal ZIP10 kidney localization, a role in renal Zn
2+
transport, and indicates that
CG10006
is a
Drosophila
homolog of ZIP10.</description><identifier>ISSN: 1931-857X</identifier><identifier>EISSN: 1522-1466</identifier><identifier>DOI: 10.1152/ajprenal.00573.2017</identifier><identifier>PMID: 30520657</identifier><language>eng</language><publisher>Bethesda, MD: American Physiological Society</publisher><ispartof>American journal of physiology. Renal physiology, 2019-02, Vol.316 (2), p.F263-F273</ispartof><rights>Copyright © 2019 the American Physiological Society 2019 American Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids></links><search><creatorcontrib>Landry, Greg M.</creatorcontrib><creatorcontrib>Furrow, Eva</creatorcontrib><creatorcontrib>Holmes, Heather L.</creatorcontrib><creatorcontrib>Hirata, Taku</creatorcontrib><creatorcontrib>Kato, Akira</creatorcontrib><creatorcontrib>Williams, Paige</creatorcontrib><creatorcontrib>Strohmaier, Käri</creatorcontrib><creatorcontrib>Gallo, Chris J. R.</creatorcontrib><creatorcontrib>Chang, Minhwang</creatorcontrib><creatorcontrib>Pandey, Mukesh K.</creatorcontrib><creatorcontrib>Jiang, Huailei</creatorcontrib><creatorcontrib>Bansal, Aditya</creatorcontrib><creatorcontrib>Franz, Marie-Christine</creatorcontrib><creatorcontrib>Montalbetti, Nicolas</creatorcontrib><creatorcontrib>Alexander, Mariam P.</creatorcontrib><creatorcontrib>Cabrero, Pablo</creatorcontrib><creatorcontrib>Dow, Julian A. T.</creatorcontrib><creatorcontrib>DeGrado, Timothy R.</creatorcontrib><creatorcontrib>Romero, Michael F.</creatorcontrib><title>Cloning, function, and localization of human, canine, and Drosophila ZIP10 (SLC39A10), a Zn2+ transporter</title><title>American journal of physiology. Renal physiology</title><description>Zinc (Zn
2+
) is the second most abundant trace element, but is considered a micronutrient, as it is a cofactor for many enzymes and transcription factors. Whereas Zn
2+
deficiency can cause cognitive immune or metabolic dysfunction and infertility, excess Zn
2+
is nephrotoxic. As for other ions and solutes, Zn
2+
is moved into and out of cells by specific membrane transporters: ZnT, Zip, and NRAMP/DMT proteins. ZIP10 is reported to be localized at the apical membrane of renal proximal tubules in rats, where it is believed to play a role in Zn
2+
import. Renal regulation of Zn
2+
is of particular interest in light of growing evidence that Zn
2+
may play a role in kidney stone formation. The objective of this study was to show that ZIP10 homologs transport Zn
2+
, as well as ZIP10, kidney localization across species. We cloned ZIP10 from dog, human, and
Drosophila
(
CG10006
), tested clones for Zn
2+
uptake in
Xenopus
oocytes and localized the protein in renal structures.
CG10006
, rather than
foi
(fear-of-intimacy,
CG6817
) is the primary ZIP10 homolog found in
Drosophila
Malpighian tubules. The ZIP10 antibody recognizes recombinant dog, human, and
Drosophila
ZIP10 proteins. Immunohistochemistry reveals that ZIP10 in higher mammals is found not only in the proximal tubule, but also in the collecting duct system. These ZIP10 proteins show Zn
2+
transport. Together, these studies reveal ZIP10 kidney localization, a role in renal Zn
2+
transport, and indicates that
CG10006
is a
Drosophila
homolog of ZIP10.</description><issn>1931-857X</issn><issn>1522-1466</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpVjl1LwzAUhoMoTqe_wJtcKq4zJ2mb9kYY9WswUFBBdlNOmnTL6JLSdoL-eiPzxnNzDu_z8HIIuQA2BUj4DW7azjhspowlUkw5A3lATgLhEcRpehjuXECUJfJjRE77fsMYA-BwTEaCJZyliTwhtmi8s241ofXOVYP1bkLRadr4Chv7jb8J9TVd77YYUIVBNnvlrvO9b9e2QbqcvwCjl6-LQuQzYFdBoEvHr-nQoetb3w2mOyNHNTa9Of_bY_L-cP9WPEWL58d5MVtEjqd8iPIEMIOs0mFSyJSATHOUiuXSpEzmGGsFVa6MxljVppKSSSmUlkJKmWglxuR239vu1NboyrjwRFO2nd1i91V6tOV_4uy6XPnPMhV5KInFD1PpZto</recordid><startdate>20190201</startdate><enddate>20190201</enddate><creator>Landry, Greg M.</creator><creator>Furrow, Eva</creator><creator>Holmes, Heather L.</creator><creator>Hirata, Taku</creator><creator>Kato, Akira</creator><creator>Williams, Paige</creator><creator>Strohmaier, Käri</creator><creator>Gallo, Chris J. R.</creator><creator>Chang, Minhwang</creator><creator>Pandey, Mukesh K.</creator><creator>Jiang, Huailei</creator><creator>Bansal, Aditya</creator><creator>Franz, Marie-Christine</creator><creator>Montalbetti, Nicolas</creator><creator>Alexander, Mariam P.</creator><creator>Cabrero, Pablo</creator><creator>Dow, Julian A. T.</creator><creator>DeGrado, Timothy R.</creator><creator>Romero, Michael F.</creator><general>American Physiological Society</general><scope>5PM</scope></search><sort><creationdate>20190201</creationdate><title>Cloning, function, and localization of human, canine, and Drosophila ZIP10 (SLC39A10), a Zn2+ transporter</title><author>Landry, Greg M. ; Furrow, Eva ; Holmes, Heather L. ; Hirata, Taku ; Kato, Akira ; Williams, Paige ; Strohmaier, Käri ; Gallo, Chris J. R. ; Chang, Minhwang ; Pandey, Mukesh K. ; Jiang, Huailei ; Bansal, Aditya ; Franz, Marie-Christine ; Montalbetti, Nicolas ; Alexander, Mariam P. ; Cabrero, Pablo ; Dow, Julian A. T. ; DeGrado, Timothy R. ; Romero, Michael F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-n262t-951a818cdddd618b318d2a7b097e6079a4db1c9beda4bfec770773bd737775db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Landry, Greg M.</creatorcontrib><creatorcontrib>Furrow, Eva</creatorcontrib><creatorcontrib>Holmes, Heather L.</creatorcontrib><creatorcontrib>Hirata, Taku</creatorcontrib><creatorcontrib>Kato, Akira</creatorcontrib><creatorcontrib>Williams, Paige</creatorcontrib><creatorcontrib>Strohmaier, Käri</creatorcontrib><creatorcontrib>Gallo, Chris J. R.</creatorcontrib><creatorcontrib>Chang, Minhwang</creatorcontrib><creatorcontrib>Pandey, Mukesh K.</creatorcontrib><creatorcontrib>Jiang, Huailei</creatorcontrib><creatorcontrib>Bansal, Aditya</creatorcontrib><creatorcontrib>Franz, Marie-Christine</creatorcontrib><creatorcontrib>Montalbetti, Nicolas</creatorcontrib><creatorcontrib>Alexander, Mariam P.</creatorcontrib><creatorcontrib>Cabrero, Pablo</creatorcontrib><creatorcontrib>Dow, Julian A. T.</creatorcontrib><creatorcontrib>DeGrado, Timothy R.</creatorcontrib><creatorcontrib>Romero, Michael F.</creatorcontrib><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of physiology. Renal physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Landry, Greg M.</au><au>Furrow, Eva</au><au>Holmes, Heather L.</au><au>Hirata, Taku</au><au>Kato, Akira</au><au>Williams, Paige</au><au>Strohmaier, Käri</au><au>Gallo, Chris J. R.</au><au>Chang, Minhwang</au><au>Pandey, Mukesh K.</au><au>Jiang, Huailei</au><au>Bansal, Aditya</au><au>Franz, Marie-Christine</au><au>Montalbetti, Nicolas</au><au>Alexander, Mariam P.</au><au>Cabrero, Pablo</au><au>Dow, Julian A. T.</au><au>DeGrado, Timothy R.</au><au>Romero, Michael F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cloning, function, and localization of human, canine, and Drosophila ZIP10 (SLC39A10), a Zn2+ transporter</atitle><jtitle>American journal of physiology. Renal physiology</jtitle><date>2019-02-01</date><risdate>2019</risdate><volume>316</volume><issue>2</issue><spage>F263</spage><epage>F273</epage><pages>F263-F273</pages><issn>1931-857X</issn><eissn>1522-1466</eissn><abstract>Zinc (Zn
2+
) is the second most abundant trace element, but is considered a micronutrient, as it is a cofactor for many enzymes and transcription factors. Whereas Zn
2+
deficiency can cause cognitive immune or metabolic dysfunction and infertility, excess Zn
2+
is nephrotoxic. As for other ions and solutes, Zn
2+
is moved into and out of cells by specific membrane transporters: ZnT, Zip, and NRAMP/DMT proteins. ZIP10 is reported to be localized at the apical membrane of renal proximal tubules in rats, where it is believed to play a role in Zn
2+
import. Renal regulation of Zn
2+
is of particular interest in light of growing evidence that Zn
2+
may play a role in kidney stone formation. The objective of this study was to show that ZIP10 homologs transport Zn
2+
, as well as ZIP10, kidney localization across species. We cloned ZIP10 from dog, human, and
Drosophila
(
CG10006
), tested clones for Zn
2+
uptake in
Xenopus
oocytes and localized the protein in renal structures.
CG10006
, rather than
foi
(fear-of-intimacy,
CG6817
) is the primary ZIP10 homolog found in
Drosophila
Malpighian tubules. The ZIP10 antibody recognizes recombinant dog, human, and
Drosophila
ZIP10 proteins. Immunohistochemistry reveals that ZIP10 in higher mammals is found not only in the proximal tubule, but also in the collecting duct system. These ZIP10 proteins show Zn
2+
transport. Together, these studies reveal ZIP10 kidney localization, a role in renal Zn
2+
transport, and indicates that
CG10006
is a
Drosophila
homolog of ZIP10.</abstract><cop>Bethesda, MD</cop><pub>American Physiological Society</pub><pmid>30520657</pmid><doi>10.1152/ajprenal.00573.2017</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1931-857X |
| ispartof | American journal of physiology. Renal physiology, 2019-02, Vol.316 (2), p.F263-F273 |
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| language | eng |
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| source | American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| title | Cloning, function, and localization of human, canine, and Drosophila ZIP10 (SLC39A10), a Zn2+ transporter |
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