Fenofibrate induces human hepatoma Hep3B cells apoptosis and necroptosis through inhibition of thioesterase domain of fatty acid synthase

This study demonstrated that fenofibrate, a lipid-lowering drug, induced a significant time-dependent cytotoxicity of hepatoma Hep3B cells. Hep3B cells are significantly more sensitive to cell killing by fenofibrate than hepatoma HepG2, lung cancer CH27 and oral cancer HSC-3 cells. From the result o...

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Veröffentlicht in:	Scientific reports 2019-03, Vol.9 (1), p.3306-3306, Article 3306
Hauptverfasser:	You, Bang-Jau, Hour, Mann-Jen, Chen, Li-Yun, Luo, Shu-Ching, Hsu, Po-Hsiang, Lee, Hong-Zin
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/2 13/95 631/154/436/2388 631/67/2195 82/80 96 96/2 96/31 Apoptosis Bcl-2 protein Binding sites Cancer Caspase Cell cycle Cell death Cyclin A Cyclin D1 Cyclin-dependent kinase 2 Cytotoxicity E protein Fatty acids Fatty-acid synthase Fenofibrate Hepatoma Humanities and Social Sciences Lipid metabolism Lipids Liver cancer Lung cancer Metabolism multidisciplinary Necroptosis Oral cancer Palmitic acid Proteins Science Science (multidisciplinary) Thioesterase
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