GABA levels and TSPO expression in people at clinical high risk for psychosis and healthy volunteers: a PET-MRS study

γ-Aminobutyric acidergic (GABAergic) dysfunction and immune activation have been implicated in the pathophysiology of schizophrenia. Preclinical evidence suggests that inflammation-related abnormalities may contribute to GABAergic alterations in the brain, but this has never been investigated in viv...

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Veröffentlicht in:	Journal of psychiatry & neuroscience 2019-03, Vol.44 (2), p.111-119
Hauptverfasser:	Da Silva, Tania, Hafizi, Sina, Rusjan, Pablo M, Houle, Sylvain, Wilson, Alan A, Prce, Ivana, Sailasuta, Napapon, Mizrahi, Romina
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Alzheimer's disease Anilides Antipsychotics Brain Cognition Cross-Sectional Studies Female GABA gamma-Aminobutyric Acid - metabolism Gene expression Genetic aspects Health aspects Humans Immune response Inflammation Magnetic resonance spectroscopy Male Measurement Medical imaging Mental disorders Multimodal Imaging Nervous system Neuroimaging Neurotransmitters Nuclear magnetic resonance spectroscopy Observations Positron emission tomography Positron-Emission Tomography - methods Prefrontal cortex Prefrontal Cortex - diagnostic imaging Prefrontal Cortex - metabolism Prodromal Symptoms Proteins Proton Magnetic Resonance Spectroscopy - methods Psychiatry Psychosis Psychotic disorders Psychotic Disorders - metabolism Psychotropic drugs Pyridines Receptors, GABA - genetics Receptors, GABA - metabolism Research Paper Risk Risk factors Schizophrenia Spectroscopy Spectrum analysis Statistical analysis Tomography Transgenic animals Translocations (Genetics) Young Adult γ-Aminobutyric acid
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