Mapping global and local coevolution across 600 species to identify novel homologous recombination repair genes

The homologous recombination repair (HRR) pathway repairs DNA double-strand breaks in an error-free manner. Mutations in HRR genes can result in increased mutation rate and genomic rearrangements, and are associated with numerous genetic disorders and cancer. Despite intensive research, the HRR path...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Genome research 2019-03, Vol.29 (3), p.439-448
Hauptverfasser:	Sherill-Rofe, Dana, Rahat, Dolev, Findlay, Steven, Mellul, Anna, Guberman, Irene, Braun, Maya, Bloch, Idit, Lalezari, Alon, Samiei, Arash, Sadreyev, Ruslan, Goldberg, Michal, Orthwein, Alexandre, Zick, Aviad, Tabach, Yuval
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Coevolution Deoxyribonucleic acid DNA DNA damage DNA repair Evolution Gene mapping Genes Genetic disorders Homologous recombination Homologous recombination repair Linkage analysis Method Mutation Mutation rates Ovarian cancer Phylogenetics Phylogeny
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!