Translational Control in Virus-Infected Cells
As obligate intracellular parasites, virus reproduction requires host cell functions. Despite variations in genome size and configuration, nucleic acid composition, and their repertoire of encoded functions, all viruses remain unconditionally dependent on the protein synthesis machinery resident wit...
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| Veröffentlicht in: | Cold Spring Harbor perspectives in biology 2019-03, Vol.11 (3), p.a033001 |
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| container_title | Cold Spring Harbor perspectives in biology |
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| creator | Stern-Ginossar, Noam Thompson, Sunnie R Mathews, Michael B Mohr, Ian |
| description | As obligate intracellular parasites, virus reproduction requires host cell functions. Despite variations in genome size and configuration, nucleic acid composition, and their repertoire of encoded functions, all viruses remain unconditionally dependent on the protein synthesis machinery resident within their cellular hosts to translate viral messenger RNAs (mRNAs). A complex signaling network responsive to physiological stress, including infection, regulates host translation factors and ribosome availability. Furthermore, access to the translation apparatus is patrolled by powerful host immune defenses programmed to restrict viral invaders. Here, we review the tactics and mechanisms used by viruses to appropriate control over host ribosomes, subvert host defenses, and dominate the infected cell translational landscape. These not only define aspects of infection biology paramount for virus reproduction, but continue to drive fundamental discoveries into how cellular protein synthesis is controlled in health and disease. |
| doi_str_mv | 10.1101/cshperspect.a033001 |
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Despite variations in genome size and configuration, nucleic acid composition, and their repertoire of encoded functions, all viruses remain unconditionally dependent on the protein synthesis machinery resident within their cellular hosts to translate viral messenger RNAs (mRNAs). A complex signaling network responsive to physiological stress, including infection, regulates host translation factors and ribosome availability. Furthermore, access to the translation apparatus is patrolled by powerful host immune defenses programmed to restrict viral invaders. Here, we review the tactics and mechanisms used by viruses to appropriate control over host ribosomes, subvert host defenses, and dominate the infected cell translational landscape. 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| subjects | Animals Disease control Gene Expression Regulation, Viral Genomes Host-Pathogen Interactions Humans Infections Nucleic acids Parasites PERSPECTIVES Physiological effects Plant Viruses - metabolism Protein Biosynthesis Protein synthesis Proteins Reproduction Ribosomes Ribosomes - metabolism RNA Processing, Post-Transcriptional Stress (physiology) Stress, Physiological Tactics Translation Viral Proteins - biosynthesis Virus Diseases - metabolism Virus Replication Viruses |
| title | Translational Control in Virus-Infected Cells |
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