Three-Dimensional and Chemical Mapping of Intracellular Signaling Nanodomains in Health and Disease with Enhanced Expansion Microscopy

Nanodomains are intracellular foci which transduce signals between major cellular compartments. One of the most ubiquitous signal transducers, the ryanodine receptor (RyR) calcium channel, is tightly clustered within these nanodomains. Super-resolution microscopy has previously been used to visualiz...

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Veröffentlicht in:	ACS nano 2019-02, Vol.13 (2), p.2143-2157, Article acsnano.8b08742
Hauptverfasser:	Sheard, Thomas M. D, Hurley, Miriam E, Colyer, John, White, Ed, Norman, Ruth, Pervolaraki, Eleftheria, Narayanasamy, Kaarjel K, Hou, Yufeng, Kirton, Hannah M, Yang, Zhaokang, Hunter, Liam, Shim, Jung-uk, Clowsley, Alexander H, Smith, Andrew J, Baddeley, David, Soeller, Christian, Colman, Michael A, Jayasinghe, Izzy
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Agonists - pharmacology Calcium - metabolism Calcium Channels - metabolism Humans Microscopy Nanostructures - chemistry Phosphorylation Ryanodine Receptor Calcium Release Channel - metabolism Signal Transduction - drug effects
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