A transgenic inducible GFP extracellular-vesicle reporter (TIGER) mouse illuminates neonatal cortical astrocytes as a source of immunomodulatory extracellular vesicles

Extracellular vesicles (EVs) are cellular derived particles found throughout the body in nearly all tissues and bodily fluids. EVs contain biological molecules including small RNAs and protein. EVs are proposed to be transferred between cells, notably, cells of the immune system. Tools that allow fo...

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Veröffentlicht in:	Scientific reports 2019-02, Vol.9 (1), p.3094-3094, Article 3094
Hauptverfasser:	Neckles, Victoria N., Morton, Mary C., Holmberg, Jennie C., Sokolov, Aidan M., Nottoli, Timothy, Liu, Don, Feliciano, David M.
Format:	Artikel
Sprache:	eng
Schlagworte:	14/19 14/69 38/91 42/41 42/89 59/5 631/1647/1511 631/378/2582 631/378/2596/1308 631/378/2596/1953 64/60 82/1 96/106 96/44 Animals Astrocytes Astrocytes - cytology Astrocytes - metabolism Biomarkers - metabolism CD11b antigen CD9 antigen Cells, Cultured Cortex Electroporation Extracellular vesicles Extracellular Vesicles - metabolism Glial fibrillary acidic protein Glutamate-ammonia ligase Glutamine Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Humanities and Social Sciences Immune system Immunomodulation Immunomodulators Lateral Ventricles - metabolism Mice Mice, Transgenic Microglia Microglia - metabolism MicroRNAs - metabolism multidisciplinary Neonates Nervous system Nestin Plasmids Pontellina plumata Proteins Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Recombinase Ribonucleic acid RNA Science Science (multidisciplinary) Subventricular zone Tamoxifen Tetraspanin 29 - genetics Tetraspanin 29 - metabolism Transgenic mice Trinucleotide repeats Ventricle (lateral)
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