Microglial Cells Impact Gut Microbiota and Gut Pathology in Angiotensin II-Induced Hypertension

RATIONALE:Increased microglial activation and neuroinflammation within autonomic brain regions have been implicated in sustained hypertension, and their inhibition by minocycline—an anti-inflammatory antibiotic—produces beneficial effects. These observations led us to propose a dysfunctional brain-g...

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Veröffentlicht in:	Circulation research 2019-03, Vol.124 (5), p.727-736
Hauptverfasser:	Sharma, Ravindra K, Yang, Tao, Oliveira, Aline C, Lobaton, Gilberto O, Aquino, Victor, Kim, Seungbum, Richards, Elaine M, Pepine, Carl J, Sumners, Colin, Raizada, Mohan K
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Animals Anti-Bacterial Agents - administration & dosage Anti-Inflammatory Agents - administration & dosage Antihypertensive Agents - administration & dosage Arterial Pressure - drug effects Autonomic Nervous System - drug effects Autonomic Nervous System - physiopathology Disease Models, Animal Gastrointestinal Microbiome - drug effects Hypertension - drug therapy Hypertension - microbiology Hypertension - pathology Hypertension - physiopathology Infusions, Intraventricular Intestines - drug effects Intestines - innervation Intestines - microbiology Intestines - pathology Male Microglia - drug effects Microglia - pathology Paraventricular Hypothalamic Nucleus - drug effects Paraventricular Hypothalamic Nucleus - pathology Paraventricular Hypothalamic Nucleus - physiopathology Rats, Inbred SHR Rats, Inbred WKY Tetracyclines - administration & dosage
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