Pre-pubertal exposure to high temperature impairs ovarian and adrenal gland function in female rats
The influence of different levels of heat exposure on the functions of ovarian and adrenal gland were investigated in pre-puberty female rats. Three-week old female rats were treated with control (26°C) or three higher temperatures (38, 40 and 42°C) for 2hr/day. After 9 days of treatment, blood samp...
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| Veröffentlicht in: | Journal of Veterinary Medical Science 2019, Vol.81(2), pp.279-286 |
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| description | The influence of different levels of heat exposure on the functions of ovarian and adrenal gland were investigated in pre-puberty female rats. Three-week old female rats were treated with control (26°C) or three higher temperatures (38, 40 and 42°C) for 2hr/day. After 9 days of treatment, blood samples were collected for measurement of luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol-17β, corticosterone, cholesterol and triglyceride. Adrenal glands, ovaries and liver were collected for analyzing gene expressions. Body and liver weight were significantly low in the 42°C heating group. Circulating LH and triglyceride in the 42°C heating group were significantly lower, and estradiol-17β, corticosterone and cholesterol were significantly higher than those of the control group. The gene expression of 3β-HSD and P450c21 in the adrenal gland; 3β-HSD, receptors of LH, FSH and estrogen in the ovary were significantly low in heated rats. The liver gene expressions of caspase 3 and NK-κB were significantly high in 42°C heated rats, suggesting that the ability of liver metabolic function reduced in the 42°C heated rats. These results demonstrated that the high temperature is responsible for suppression of ovarian function by decreasing the expression of steroidogenic enzymes, estrogen and gonadotropin receptors in the ovary. Increase in circulating estradiol-17β in the heated rats may be due to accumulate this hormone in circulation by potential changes in liver metabolism during the heat stress. |
| doi_str_mv | 10.1292/jvms.18-0644 |
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Three-week old female rats were treated with control (26°C) or three higher temperatures (38, 40 and 42°C) for 2hr/day. After 9 days of treatment, blood samples were collected for measurement of luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol-17β, corticosterone, cholesterol and triglyceride. Adrenal glands, ovaries and liver were collected for analyzing gene expressions. Body and liver weight were significantly low in the 42°C heating group. Circulating LH and triglyceride in the 42°C heating group were significantly lower, and estradiol-17β, corticosterone and cholesterol were significantly higher than those of the control group. The gene expression of 3β-HSD and P450c21 in the adrenal gland; 3β-HSD, receptors of LH, FSH and estrogen in the ovary were significantly low in heated rats. The liver gene expressions of caspase 3 and NK-κB were significantly high in 42°C heated rats, suggesting that the ability of liver metabolic function reduced in the 42°C heated rats. These results demonstrated that the high temperature is responsible for suppression of ovarian function by decreasing the expression of steroidogenic enzymes, estrogen and gonadotropin receptors in the ovary. Increase in circulating estradiol-17β in the heated rats may be due to accumulate this hormone in circulation by potential changes in liver metabolism during the heat stress.</description><identifier>ISSN: 0916-7250</identifier><identifier>EISSN: 1347-7439</identifier><identifier>DOI: 10.1292/jvms.18-0644</identifier><identifier>PMID: 30587674</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE</publisher><subject>17β-Estradiol ; Adrenal glands ; Caspase ; Caspase-3 ; Cholesterol ; Corticosterone ; estradiol-17β ; Estrogens ; Exposure ; Follicle-stimulating hormone ; Gene expression ; Gonadotropins ; Heat stress ; Heat tolerance ; High temperature ; Liver ; Luteinizing hormone ; Metabolism ; Ovaries ; Physiology ; Pituitary (anterior) ; Puberty ; rat ; Receptor mechanisms ; Reproductive status ; Rodents ; steroidogenesis</subject><ispartof>Journal of Veterinary Medical Science, 2019, Vol.81(2), pp.279-286</ispartof><rights>2019 by the Japanese Society of Veterinary Science</rights><rights>Copyright Japan Science and Technology Agency Feb 2019</rights><rights>2019 The Japanese Society of Veterinary Science 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c618t-d1df339d454464aa854b97b705c59f66da3bd00d212d699dccd4cdbd8d0bb7013</citedby><cites>FETCH-LOGICAL-c618t-d1df339d454464aa854b97b705c59f66da3bd00d212d699dccd4cdbd8d0bb7013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395223/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395223/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1881,4022,27921,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30587674$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ZHENG, Meihua</creatorcontrib><creatorcontrib>NAGAOKA, Kentaro</creatorcontrib><creatorcontrib>WATANABE, Gen</creatorcontrib><title>Pre-pubertal exposure to high temperature impairs ovarian and adrenal gland function in female rats</title><title>Journal of Veterinary Medical Science</title><addtitle>J. Vet. Med. Sci.</addtitle><description>The influence of different levels of heat exposure on the functions of ovarian and adrenal gland were investigated in pre-puberty female rats. Three-week old female rats were treated with control (26°C) or three higher temperatures (38, 40 and 42°C) for 2hr/day. After 9 days of treatment, blood samples were collected for measurement of luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol-17β, corticosterone, cholesterol and triglyceride. Adrenal glands, ovaries and liver were collected for analyzing gene expressions. Body and liver weight were significantly low in the 42°C heating group. Circulating LH and triglyceride in the 42°C heating group were significantly lower, and estradiol-17β, corticosterone and cholesterol were significantly higher than those of the control group. The gene expression of 3β-HSD and P450c21 in the adrenal gland; 3β-HSD, receptors of LH, FSH and estrogen in the ovary were significantly low in heated rats. The liver gene expressions of caspase 3 and NK-κB were significantly high in 42°C heated rats, suggesting that the ability of liver metabolic function reduced in the 42°C heated rats. These results demonstrated that the high temperature is responsible for suppression of ovarian function by decreasing the expression of steroidogenic enzymes, estrogen and gonadotropin receptors in the ovary. Increase in circulating estradiol-17β in the heated rats may be due to accumulate this hormone in circulation by potential changes in liver metabolism during the heat stress.</description><subject>17β-Estradiol</subject><subject>Adrenal glands</subject><subject>Caspase</subject><subject>Caspase-3</subject><subject>Cholesterol</subject><subject>Corticosterone</subject><subject>estradiol-17β</subject><subject>Estrogens</subject><subject>Exposure</subject><subject>Follicle-stimulating hormone</subject><subject>Gene expression</subject><subject>Gonadotropins</subject><subject>Heat stress</subject><subject>Heat tolerance</subject><subject>High temperature</subject><subject>Liver</subject><subject>Luteinizing hormone</subject><subject>Metabolism</subject><subject>Ovaries</subject><subject>Physiology</subject><subject>Pituitary (anterior)</subject><subject>Puberty</subject><subject>rat</subject><subject>Receptor mechanisms</subject><subject>Reproductive status</subject><subject>Rodents</subject><subject>steroidogenesis</subject><issn>0916-7250</issn><issn>1347-7439</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpdkc1v1DAQxS1ERZfCjTOyxIUDKf6KE1-QSsVHpUrlAGfLsSe7XiVxsJ0V_Pc42mUFvXhkz2-e_OYh9IqSa8oUe78_jOmathWRQjxBG8pFUzWCq6doQxSVVcNqcomep7QnhFEh1TN0yUndNrIRG2S_RajmpYOYzYDh1xzSEgHngHd-u8MZxhmiyeubH2fjY8LhYKI3EzaTw8ZFmMrgdlhv_TLZ7MOE_YR7GM0AuMymF-iiN0OCl6d6hX58_vT99mt1__Dl7vbmvrKStrly1PWcKydqIaQwpq1Fp5quIbWtVS-lM7xzhDhGmZNKOWudsK5zrSNdoSi_Qh-OusXPCM7ClKMZ9Bz9aOJvHYzX_3cmv9PbcNCSq5oxXgTengRi-LlAynr0ycJQzEFYkmZUUiJZ27KCvnmE7sMSyyoKxbiStFG0LtS7I2VjSClCf_4MJXpNT6_padrqNb2Cv_7XwBn-G1cBPh6BfcpmC2fAxOztAEe1lmq2HifVc9PuTNQw8T_CRLBl</recordid><startdate>2019</startdate><enddate>2019</enddate><creator>ZHENG, Meihua</creator><creator>NAGAOKA, Kentaro</creator><creator>WATANABE, Gen</creator><general>JAPANESE SOCIETY OF VETERINARY SCIENCE</general><general>Japan Science and Technology Agency</general><general>The Japanese Society of Veterinary Science</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2019</creationdate><title>Pre-pubertal exposure to high temperature impairs ovarian and adrenal gland function in female rats</title><author>ZHENG, Meihua ; NAGAOKA, Kentaro ; WATANABE, Gen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c618t-d1df339d454464aa854b97b705c59f66da3bd00d212d699dccd4cdbd8d0bb7013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>17β-Estradiol</topic><topic>Adrenal glands</topic><topic>Caspase</topic><topic>Caspase-3</topic><topic>Cholesterol</topic><topic>Corticosterone</topic><topic>estradiol-17β</topic><topic>Estrogens</topic><topic>Exposure</topic><topic>Follicle-stimulating hormone</topic><topic>Gene expression</topic><topic>Gonadotropins</topic><topic>Heat stress</topic><topic>Heat tolerance</topic><topic>High temperature</topic><topic>Liver</topic><topic>Luteinizing hormone</topic><topic>Metabolism</topic><topic>Ovaries</topic><topic>Physiology</topic><topic>Pituitary (anterior)</topic><topic>Puberty</topic><topic>rat</topic><topic>Receptor mechanisms</topic><topic>Reproductive status</topic><topic>Rodents</topic><topic>steroidogenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ZHENG, Meihua</creatorcontrib><creatorcontrib>NAGAOKA, Kentaro</creatorcontrib><creatorcontrib>WATANABE, Gen</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Veterinary Medical Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ZHENG, Meihua</au><au>NAGAOKA, Kentaro</au><au>WATANABE, Gen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pre-pubertal exposure to high temperature impairs ovarian and adrenal gland function in female rats</atitle><jtitle>Journal of Veterinary Medical Science</jtitle><addtitle>J. Vet. Med. Sci.</addtitle><date>2019</date><risdate>2019</risdate><volume>81</volume><issue>2</issue><spage>279</spage><epage>286</epage><pages>279-286</pages><issn>0916-7250</issn><eissn>1347-7439</eissn><abstract>The influence of different levels of heat exposure on the functions of ovarian and adrenal gland were investigated in pre-puberty female rats. Three-week old female rats were treated with control (26°C) or three higher temperatures (38, 40 and 42°C) for 2hr/day. After 9 days of treatment, blood samples were collected for measurement of luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol-17β, corticosterone, cholesterol and triglyceride. Adrenal glands, ovaries and liver were collected for analyzing gene expressions. Body and liver weight were significantly low in the 42°C heating group. Circulating LH and triglyceride in the 42°C heating group were significantly lower, and estradiol-17β, corticosterone and cholesterol were significantly higher than those of the control group. The gene expression of 3β-HSD and P450c21 in the adrenal gland; 3β-HSD, receptors of LH, FSH and estrogen in the ovary were significantly low in heated rats. The liver gene expressions of caspase 3 and NK-κB were significantly high in 42°C heated rats, suggesting that the ability of liver metabolic function reduced in the 42°C heated rats. These results demonstrated that the high temperature is responsible for suppression of ovarian function by decreasing the expression of steroidogenic enzymes, estrogen and gonadotropin receptors in the ovary. Increase in circulating estradiol-17β in the heated rats may be due to accumulate this hormone in circulation by potential changes in liver metabolism during the heat stress.</abstract><cop>Japan</cop><pub>JAPANESE SOCIETY OF VETERINARY SCIENCE</pub><pmid>30587674</pmid><doi>10.1292/jvms.18-0644</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 17β-Estradiol Adrenal glands Caspase Caspase-3 Cholesterol Corticosterone estradiol-17β Estrogens Exposure Follicle-stimulating hormone Gene expression Gonadotropins Heat stress Heat tolerance High temperature Liver Luteinizing hormone Metabolism Ovaries Physiology Pituitary (anterior) Puberty rat Receptor mechanisms Reproductive status Rodents steroidogenesis |
| title | Pre-pubertal exposure to high temperature impairs ovarian and adrenal gland function in female rats |
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