Killing Two Angry Birds with One Stone: Autophagy Activation by Inhibiting Calpains in Neurodegenerative Diseases and Beyond
Proteolytic machineries execute vital cellular functions and their disturbances are implicated in diverse medical conditions, including neurodegenerative diseases. Interestingly, calpains, a class of Ca2+-dependent regulatory proteases, can modulate the degradational system of autophagy by cleaving...
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| Veröffentlicht in: | BioMed research international 2019-01, Vol.2019 (2019), p.1-13 |
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| creator | Nguyen, Huu Phuc Singer, Elisabeth Pereira Sena, Priscila Weber, Jonasz Jeremiasz |
| description | Proteolytic machineries execute vital cellular functions and their disturbances are implicated in diverse medical conditions, including neurodegenerative diseases. Interestingly, calpains, a class of Ca2+-dependent regulatory proteases, can modulate the degradational system of autophagy by cleaving proteins involved in this pathway. Moreover, both machineries are common players in many molecular pathomechanisms and have been targeted individually or together, as a therapeutic strategy in experimental setups. In this review, we briefly introduce calpains and autophagy, with their roles in health and disease, and focus on their direct pathologically relevant interplay in neurodegeneration and beyond. The modulation of calpain activity may comprise a promising treatment approach to attenuate the deregulation of these two essential mechanisms. |
| doi_str_mv | 10.1155/2019/4741252 |
| format | Article |
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Interestingly, calpains, a class of Ca2+-dependent regulatory proteases, can modulate the degradational system of autophagy by cleaving proteins involved in this pathway. Moreover, both machineries are common players in many molecular pathomechanisms and have been targeted individually or together, as a therapeutic strategy in experimental setups. In this review, we briefly introduce calpains and autophagy, with their roles in health and disease, and focus on their direct pathologically relevant interplay in neurodegeneration and beyond. The modulation of calpain activity may comprise a promising treatment approach to attenuate the deregulation of these two essential mechanisms.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2019/4741252</identifier><identifier>PMID: 30895192</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Animals ; Apoptosis ; Autophagy ; Calcium ; Calcium ions ; Calpain ; Calpain - antagonists & inhibitors ; Calpain - chemistry ; Calpain - metabolism ; Cell cycle ; Deregulation ; Disease ; Enzymes ; Gene expression ; Glycoproteins - pharmacology ; Glycoproteins - therapeutic use ; Homeostasis ; Humans ; Ischemia ; Models, Biological ; Mutation ; Neurodegeneration ; Neurodegenerative diseases ; Neurodegenerative Diseases - drug therapy ; Neurodegenerative Diseases - pathology ; Neurological diseases ; Phagocytosis ; Physiology ; Proteins ; Proteolysis ; Review ; Signal transduction ; Stem cells</subject><ispartof>BioMed research international, 2019-01, Vol.2019 (2019), p.1-13</ispartof><rights>Copyright © 2019 Jonasz Jeremiasz Weber et al.</rights><rights>Copyright © 2019 Jonasz Jeremiasz Weber et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 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| subjects | Animals Apoptosis Autophagy Calcium Calcium ions Calpain Calpain - antagonists & inhibitors Calpain - chemistry Calpain - metabolism Cell cycle Deregulation Disease Enzymes Gene expression Glycoproteins - pharmacology Glycoproteins - therapeutic use Homeostasis Humans Ischemia Models, Biological Mutation Neurodegeneration Neurodegenerative diseases Neurodegenerative Diseases - drug therapy Neurodegenerative Diseases - pathology Neurological diseases Phagocytosis Physiology Proteins Proteolysis Review Signal transduction Stem cells |
| title | Killing Two Angry Birds with One Stone: Autophagy Activation by Inhibiting Calpains in Neurodegenerative Diseases and Beyond |
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