Dystrophic calcinosis in a patient with overlap syndrome (scleroderma and rheumatoid arthritis) treated by leflunomide: A case report
Dystrophic calcinosis occurs in chronically damaged tissue in patients with complicated autoimmune diseases. The therapeutic options are limited, and the treatment response rate is variable. Here, we describe a rare case of dystrophic calcinosis treated with leflunomide in a patient with overlap syn...
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| Veröffentlicht in: | Medicine (Baltimore) 2018-11, Vol.97 (47), p.e13319-e13319 |
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| container_issue | 47 |
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| creator | Lee, Sang Yeob Lee, Sung Won Chung, Won Tae |
| description | Dystrophic calcinosis occurs in chronically damaged tissue in patients with complicated autoimmune diseases. The therapeutic options are limited, and the treatment response rate is variable. Here, we describe a rare case of dystrophic calcinosis treated with leflunomide in a patient with overlap syndrome.
A 53-year-old woman who was diagnosed with overlaps syndrome (systemic sclerosis [SSc] with rheumatoid arthritis [RA]), presented to our hospital with pain and swelling in both wrists, and underwent radiography, bone scan, and biopsy examination.
This patient was diagnosed with dystrophic calcinosis in overlaps syndrome.
The conventional disease-modifying drugs were not effective. Hence, leflunomide was administered.
Simple radiography and bone scan showed resolved mass-like dystrophic calcinosis on both wrists of the patient after the use of leflunomide.
The control of underlying disease is important in the treatment of dystrophic calcinosis. The use of leflunomide maybe an option in treatment of dystrophic calcinosis combined with RA. |
| doi_str_mv | 10.1097/MD.0000000000013319 |
| format | Article |
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A 53-year-old woman who was diagnosed with overlaps syndrome (systemic sclerosis [SSc] with rheumatoid arthritis [RA]), presented to our hospital with pain and swelling in both wrists, and underwent radiography, bone scan, and biopsy examination.
This patient was diagnosed with dystrophic calcinosis in overlaps syndrome.
The conventional disease-modifying drugs were not effective. Hence, leflunomide was administered.
Simple radiography and bone scan showed resolved mass-like dystrophic calcinosis on both wrists of the patient after the use of leflunomide.
The control of underlying disease is important in the treatment of dystrophic calcinosis. The use of leflunomide maybe an option in treatment of dystrophic calcinosis combined with RA.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000013319</identifier><identifier>PMID: 30461645</identifier><language>eng</language><publisher>United States: the Author(s). Published by Wolters Kluwer Health, Inc</publisher><subject>Arthritis, Rheumatoid - complications ; Arthritis, Rheumatoid - drug therapy ; Calcinosis - drug therapy ; Calcinosis - etiology ; Calcinosis - pathology ; Clinical Case Report ; Female ; Humans ; Immunosuppressive Agents - therapeutic use ; Leflunomide - therapeutic use ; Middle Aged ; Scleroderma, Systemic - complications ; Scleroderma, Systemic - drug therapy ; Undifferentiated Connective Tissue Diseases - complications ; Undifferentiated Connective Tissue Diseases - drug therapy</subject><ispartof>Medicine (Baltimore), 2018-11, Vol.97 (47), p.e13319-e13319</ispartof><rights>the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3556-c4c6d32901e93e3b678c5db4f4517137bde37638d85e29b0fd7a85f7895a54313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393103/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393103/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30461645$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Sang Yeob</creatorcontrib><creatorcontrib>Lee, Sung Won</creatorcontrib><creatorcontrib>Chung, Won Tae</creatorcontrib><title>Dystrophic calcinosis in a patient with overlap syndrome (scleroderma and rheumatoid arthritis) treated by leflunomide: A case report</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>Dystrophic calcinosis occurs in chronically damaged tissue in patients with complicated autoimmune diseases. The therapeutic options are limited, and the treatment response rate is variable. Here, we describe a rare case of dystrophic calcinosis treated with leflunomide in a patient with overlap syndrome.
A 53-year-old woman who was diagnosed with overlaps syndrome (systemic sclerosis [SSc] with rheumatoid arthritis [RA]), presented to our hospital with pain and swelling in both wrists, and underwent radiography, bone scan, and biopsy examination.
This patient was diagnosed with dystrophic calcinosis in overlaps syndrome.
The conventional disease-modifying drugs were not effective. Hence, leflunomide was administered.
Simple radiography and bone scan showed resolved mass-like dystrophic calcinosis on both wrists of the patient after the use of leflunomide.
The control of underlying disease is important in the treatment of dystrophic calcinosis. The use of leflunomide maybe an option in treatment of dystrophic calcinosis combined with RA.</description><subject>Arthritis, Rheumatoid - complications</subject><subject>Arthritis, Rheumatoid - drug therapy</subject><subject>Calcinosis - drug therapy</subject><subject>Calcinosis - etiology</subject><subject>Calcinosis - pathology</subject><subject>Clinical Case Report</subject><subject>Female</subject><subject>Humans</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Leflunomide - therapeutic use</subject><subject>Middle Aged</subject><subject>Scleroderma, Systemic - complications</subject><subject>Scleroderma, Systemic - drug therapy</subject><subject>Undifferentiated Connective Tissue Diseases - complications</subject><subject>Undifferentiated Connective Tissue Diseases - drug therapy</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkctu1TAQhiMEoqeFJ0BCXraLFN-dsECqeiggtWIDa8uxJ8TgxMF2enQegPcm5ZRymc1IM9_8M6O_ql4QfE5wq17dbM_xnyCMkfZRtSGCyVq0kj-uNhhTUatW8aPqOOevd5Ci_Gl1xDCXRHKxqX5s97mkOA_eImuC9VPMPiM_IYNmUzxMBe18GVC8hRTMjPJ-cimOgE6zDZCigzQaZCaH0gDLaEr0DplUhuSLz2eoJDAFHOr2KEAflimO3sFrdLGuy4ASzDGVZ9WT3oQMz-_zSfX56u2ny_f19cd3Hy4vrmvLhJC15VY6RltMoGXAOqkaK1zHey6IWn_rHDAlWeMaAbTtcO-UaUSvmlYYwRlhJ9Wbg-68dCM4u36XTNBz8qNJex2N1_92Jj_oL_FWS9YygtkqcHovkOL3BXLRo88WQjATxCVrSpgUglJBV5QdUJtizgn6hzUE6zsD9c1W_2_gOvXy7wsfZn47tgL8AOxiKJDyt7DsIOkBTCjDLz2hWlpTTBpCKMH1WuGS_QSKw6ih</recordid><startdate>20181101</startdate><enddate>20181101</enddate><creator>Lee, Sang Yeob</creator><creator>Lee, Sung Won</creator><creator>Chung, Won Tae</creator><general>the Author(s). Published by Wolters Kluwer Health, Inc</general><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181101</creationdate><title>Dystrophic calcinosis in a patient with overlap syndrome (scleroderma and rheumatoid arthritis) treated by leflunomide: A case report</title><author>Lee, Sang Yeob ; Lee, Sung Won ; Chung, Won Tae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3556-c4c6d32901e93e3b678c5db4f4517137bde37638d85e29b0fd7a85f7895a54313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Arthritis, Rheumatoid - complications</topic><topic>Arthritis, Rheumatoid - drug therapy</topic><topic>Calcinosis - drug therapy</topic><topic>Calcinosis - etiology</topic><topic>Calcinosis - pathology</topic><topic>Clinical Case Report</topic><topic>Female</topic><topic>Humans</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Leflunomide - therapeutic use</topic><topic>Middle Aged</topic><topic>Scleroderma, Systemic - complications</topic><topic>Scleroderma, Systemic - drug therapy</topic><topic>Undifferentiated Connective Tissue Diseases - complications</topic><topic>Undifferentiated Connective Tissue Diseases - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Sang Yeob</creatorcontrib><creatorcontrib>Lee, Sung Won</creatorcontrib><creatorcontrib>Chung, Won Tae</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Sang Yeob</au><au>Lee, Sung Won</au><au>Chung, Won Tae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dystrophic calcinosis in a patient with overlap syndrome (scleroderma and rheumatoid arthritis) treated by leflunomide: A case report</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2018-11-01</date><risdate>2018</risdate><volume>97</volume><issue>47</issue><spage>e13319</spage><epage>e13319</epage><pages>e13319-e13319</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>Dystrophic calcinosis occurs in chronically damaged tissue in patients with complicated autoimmune diseases. The therapeutic options are limited, and the treatment response rate is variable. Here, we describe a rare case of dystrophic calcinosis treated with leflunomide in a patient with overlap syndrome.
A 53-year-old woman who was diagnosed with overlaps syndrome (systemic sclerosis [SSc] with rheumatoid arthritis [RA]), presented to our hospital with pain and swelling in both wrists, and underwent radiography, bone scan, and biopsy examination.
This patient was diagnosed with dystrophic calcinosis in overlaps syndrome.
The conventional disease-modifying drugs were not effective. Hence, leflunomide was administered.
Simple radiography and bone scan showed resolved mass-like dystrophic calcinosis on both wrists of the patient after the use of leflunomide.
The control of underlying disease is important in the treatment of dystrophic calcinosis. The use of leflunomide maybe an option in treatment of dystrophic calcinosis combined with RA.</abstract><cop>United States</cop><pub>the Author(s). Published by Wolters Kluwer Health, Inc</pub><pmid>30461645</pmid><doi>10.1097/MD.0000000000013319</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Wolters Kluwer Open Health; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - drug therapy Calcinosis - drug therapy Calcinosis - etiology Calcinosis - pathology Clinical Case Report Female Humans Immunosuppressive Agents - therapeutic use Leflunomide - therapeutic use Middle Aged Scleroderma, Systemic - complications Scleroderma, Systemic - drug therapy Undifferentiated Connective Tissue Diseases - complications Undifferentiated Connective Tissue Diseases - drug therapy |
| title | Dystrophic calcinosis in a patient with overlap syndrome (scleroderma and rheumatoid arthritis) treated by leflunomide: A case report |
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