Acute vanishing bile duct syndrome after therapy with cephalosporin, metronidazole, and clotrimazole: A case report
Vanishing bile duct syndrome (VBDS) consists of a series of diseases characterized by the loss of >50% bile duct in portal areas. Many factors are associated with VBDS including infections, neoplasms, and drugs. Antibiotic is one of the most frequently reported causes of VBDS. A 29-year-old femal...
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| Veröffentlicht in: | Medicine (Baltimore) 2017-09, Vol.96 (36), p.e8009-e8009 |
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| container_title | Medicine (Baltimore) |
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| creator | Zhao, Zonghao Bao, Lei Yu, Xiaolan Zhu, Chuanlong Xu, Jing Wang, Yu Yin, Ming Li, Yi Li, Wenting |
| description | Vanishing bile duct syndrome (VBDS) consists of a series of diseases characterized by the loss of >50% bile duct in portal areas. Many factors are associated with VBDS including infections, neoplasms, and drugs. Antibiotic is one of the most frequently reported causes of VBDS.
A 29-year-old female was admitted because of liver injury for over 3 months. Tests for viruses that can cause hepatitis and autoantibodies were all negative. She was prescribed with antibiotics approximately a week before liver injury while there was no history of alcohol consumption.
Liver biopsy demonstrated a loss of intrahepatic bile duct in most of the portal tracts.
This patient was treated with ursodeoxycholic acid, polyene phosphatidylcholine, and bicyclol. Most importantly, the treatments in our hospital were proved by the ethics committee of Department of Infectious Disease, Anhui Provincial Hospital.
The symptoms were improved. She is still under treatment.
VBDS is rare but can be severe. A liver biopsy offers an important evidence for the diagnosis of VBDS, especially for those with a history of susceptible drugs taking. |
| doi_str_mv | 10.1097/MD.0000000000008009 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6392967</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>28885366</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2856-f52c7fe40607e8fa37d637f0fe3efa95b72218e2aa591847dd1bd62f8869dca83</originalsourceid><addsrcrecordid>eNpdkdtuFDEMhiMEokvhCZBQHqBTcpjJgQukVctJasUNXEfZxOkEspNRku1qeXqmXagKvrFk__9ny0boNSXnlGj59vrynDwKRYh-glZ04KIbtOifohUhbOiklv0JelHrD0Iol6x_jk6YUmrRiRWqa7drgG_tFOsYpxu8iQmw37mG62HyJW8B29Cg4DZCsfMB72MbsYN5tCnXOZc4neEttJKn6O2vnOAM28ljl3IrcXtfeYfX2NkKuMBiaC_Rs2BThVd_8in6_vHDt4vP3dXXT18u1ledY2oQXRiYkwF6IogEFSyXXnAZSAAOwephIxmjCpi1g6aql97TjRcsKCW0d1bxU_T-yJ13my14B1MrNpn5bq1yMNlG829niqO5ybdGcM20kAuAHwGu5FoLhAcvJebuB-b60vz_g8X15vHYB8_foy-C_ijY57Rctv5Muz0UM4JNbbznDVKzjhEqiV6Y3VLpBf8NAsuVZA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Acute vanishing bile duct syndrome after therapy with cephalosporin, metronidazole, and clotrimazole: A case report</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Wolters Kluwer Open Health</source><source>IngentaConnect Free/Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Zhao, Zonghao ; Bao, Lei ; Yu, Xiaolan ; Zhu, Chuanlong ; Xu, Jing ; Wang, Yu ; Yin, Ming ; Li, Yi ; Li, Wenting</creator><creatorcontrib>Zhao, Zonghao ; Bao, Lei ; Yu, Xiaolan ; Zhu, Chuanlong ; Xu, Jing ; Wang, Yu ; Yin, Ming ; Li, Yi ; Li, Wenting</creatorcontrib><description>Vanishing bile duct syndrome (VBDS) consists of a series of diseases characterized by the loss of >50% bile duct in portal areas. Many factors are associated with VBDS including infections, neoplasms, and drugs. Antibiotic is one of the most frequently reported causes of VBDS.
A 29-year-old female was admitted because of liver injury for over 3 months. Tests for viruses that can cause hepatitis and autoantibodies were all negative. She was prescribed with antibiotics approximately a week before liver injury while there was no history of alcohol consumption.
Liver biopsy demonstrated a loss of intrahepatic bile duct in most of the portal tracts.
This patient was treated with ursodeoxycholic acid, polyene phosphatidylcholine, and bicyclol. Most importantly, the treatments in our hospital were proved by the ethics committee of Department of Infectious Disease, Anhui Provincial Hospital.
The symptoms were improved. She is still under treatment.
VBDS is rare but can be severe. A liver biopsy offers an important evidence for the diagnosis of VBDS, especially for those with a history of susceptible drugs taking.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000008009</identifier><identifier>PMID: 28885366</identifier><language>eng</language><publisher>United States: The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Adult ; Anti-Bacterial Agents - adverse effects ; Anti-Bacterial Agents - therapeutic use ; Bile Duct Diseases - chemically induced ; Bile Duct Diseases - pathology ; Bile Ducts, Intrahepatic - drug effects ; Bile Ducts, Intrahepatic - pathology ; Cephalosporins - adverse effects ; Cephalosporins - therapeutic use ; Clinical Case Report ; Clotrimazole - adverse effects ; Clotrimazole - therapeutic use ; Drug Therapy, Combination ; Female ; Humans ; Metronidazole - adverse effects ; Metronidazole - therapeutic use ; Syndrome</subject><ispartof>Medicine (Baltimore), 2017-09, Vol.96 (36), p.e8009-e8009</ispartof><rights>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.</rights><rights>Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2856-f52c7fe40607e8fa37d637f0fe3efa95b72218e2aa591847dd1bd62f8869dca83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392967/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392967/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28885366$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Zonghao</creatorcontrib><creatorcontrib>Bao, Lei</creatorcontrib><creatorcontrib>Yu, Xiaolan</creatorcontrib><creatorcontrib>Zhu, Chuanlong</creatorcontrib><creatorcontrib>Xu, Jing</creatorcontrib><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Yin, Ming</creatorcontrib><creatorcontrib>Li, Yi</creatorcontrib><creatorcontrib>Li, Wenting</creatorcontrib><title>Acute vanishing bile duct syndrome after therapy with cephalosporin, metronidazole, and clotrimazole: A case report</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>Vanishing bile duct syndrome (VBDS) consists of a series of diseases characterized by the loss of >50% bile duct in portal areas. Many factors are associated with VBDS including infections, neoplasms, and drugs. Antibiotic is one of the most frequently reported causes of VBDS.
A 29-year-old female was admitted because of liver injury for over 3 months. Tests for viruses that can cause hepatitis and autoantibodies were all negative. She was prescribed with antibiotics approximately a week before liver injury while there was no history of alcohol consumption.
Liver biopsy demonstrated a loss of intrahepatic bile duct in most of the portal tracts.
This patient was treated with ursodeoxycholic acid, polyene phosphatidylcholine, and bicyclol. Most importantly, the treatments in our hospital were proved by the ethics committee of Department of Infectious Disease, Anhui Provincial Hospital.
The symptoms were improved. She is still under treatment.
VBDS is rare but can be severe. A liver biopsy offers an important evidence for the diagnosis of VBDS, especially for those with a history of susceptible drugs taking.</description><subject>Adult</subject><subject>Anti-Bacterial Agents - adverse effects</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Bile Duct Diseases - chemically induced</subject><subject>Bile Duct Diseases - pathology</subject><subject>Bile Ducts, Intrahepatic - drug effects</subject><subject>Bile Ducts, Intrahepatic - pathology</subject><subject>Cephalosporins - adverse effects</subject><subject>Cephalosporins - therapeutic use</subject><subject>Clinical Case Report</subject><subject>Clotrimazole - adverse effects</subject><subject>Clotrimazole - therapeutic use</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Humans</subject><subject>Metronidazole - adverse effects</subject><subject>Metronidazole - therapeutic use</subject><subject>Syndrome</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkdtuFDEMhiMEokvhCZBQHqBTcpjJgQukVctJasUNXEfZxOkEspNRku1qeXqmXagKvrFk__9ny0boNSXnlGj59vrynDwKRYh-glZ04KIbtOifohUhbOiklv0JelHrD0Iol6x_jk6YUmrRiRWqa7drgG_tFOsYpxu8iQmw37mG62HyJW8B29Cg4DZCsfMB72MbsYN5tCnXOZc4neEttJKn6O2vnOAM28ljl3IrcXtfeYfX2NkKuMBiaC_Rs2BThVd_8in6_vHDt4vP3dXXT18u1ledY2oQXRiYkwF6IogEFSyXXnAZSAAOwephIxmjCpi1g6aql97TjRcsKCW0d1bxU_T-yJ13my14B1MrNpn5bq1yMNlG829niqO5ybdGcM20kAuAHwGu5FoLhAcvJebuB-b60vz_g8X15vHYB8_foy-C_ijY57Rctv5Muz0UM4JNbbznDVKzjhEqiV6Y3VLpBf8NAsuVZA</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Zhao, Zonghao</creator><creator>Bao, Lei</creator><creator>Yu, Xiaolan</creator><creator>Zhu, Chuanlong</creator><creator>Xu, Jing</creator><creator>Wang, Yu</creator><creator>Yin, Ming</creator><creator>Li, Yi</creator><creator>Li, Wenting</creator><general>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</general><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20170901</creationdate><title>Acute vanishing bile duct syndrome after therapy with cephalosporin, metronidazole, and clotrimazole: A case report</title><author>Zhao, Zonghao ; Bao, Lei ; Yu, Xiaolan ; Zhu, Chuanlong ; Xu, Jing ; Wang, Yu ; Yin, Ming ; Li, Yi ; Li, Wenting</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2856-f52c7fe40607e8fa37d637f0fe3efa95b72218e2aa591847dd1bd62f8869dca83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Anti-Bacterial Agents - adverse effects</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Bile Duct Diseases - chemically induced</topic><topic>Bile Duct Diseases - pathology</topic><topic>Bile Ducts, Intrahepatic - drug effects</topic><topic>Bile Ducts, Intrahepatic - pathology</topic><topic>Cephalosporins - adverse effects</topic><topic>Cephalosporins - therapeutic use</topic><topic>Clinical Case Report</topic><topic>Clotrimazole - adverse effects</topic><topic>Clotrimazole - therapeutic use</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Humans</topic><topic>Metronidazole - adverse effects</topic><topic>Metronidazole - therapeutic use</topic><topic>Syndrome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Zonghao</creatorcontrib><creatorcontrib>Bao, Lei</creatorcontrib><creatorcontrib>Yu, Xiaolan</creatorcontrib><creatorcontrib>Zhu, Chuanlong</creatorcontrib><creatorcontrib>Xu, Jing</creatorcontrib><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Yin, Ming</creatorcontrib><creatorcontrib>Li, Yi</creatorcontrib><creatorcontrib>Li, Wenting</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Zonghao</au><au>Bao, Lei</au><au>Yu, Xiaolan</au><au>Zhu, Chuanlong</au><au>Xu, Jing</au><au>Wang, Yu</au><au>Yin, Ming</au><au>Li, Yi</au><au>Li, Wenting</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute vanishing bile duct syndrome after therapy with cephalosporin, metronidazole, and clotrimazole: A case report</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>96</volume><issue>36</issue><spage>e8009</spage><epage>e8009</epage><pages>e8009-e8009</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>Vanishing bile duct syndrome (VBDS) consists of a series of diseases characterized by the loss of >50% bile duct in portal areas. Many factors are associated with VBDS including infections, neoplasms, and drugs. Antibiotic is one of the most frequently reported causes of VBDS.
A 29-year-old female was admitted because of liver injury for over 3 months. Tests for viruses that can cause hepatitis and autoantibodies were all negative. She was prescribed with antibiotics approximately a week before liver injury while there was no history of alcohol consumption.
Liver biopsy demonstrated a loss of intrahepatic bile duct in most of the portal tracts.
This patient was treated with ursodeoxycholic acid, polyene phosphatidylcholine, and bicyclol. Most importantly, the treatments in our hospital were proved by the ethics committee of Department of Infectious Disease, Anhui Provincial Hospital.
The symptoms were improved. She is still under treatment.
VBDS is rare but can be severe. A liver biopsy offers an important evidence for the diagnosis of VBDS, especially for those with a history of susceptible drugs taking.</abstract><cop>United States</cop><pub>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>28885366</pmid><doi>10.1097/MD.0000000000008009</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Wolters Kluwer Open Health; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - therapeutic use Bile Duct Diseases - chemically induced Bile Duct Diseases - pathology Bile Ducts, Intrahepatic - drug effects Bile Ducts, Intrahepatic - pathology Cephalosporins - adverse effects Cephalosporins - therapeutic use Clinical Case Report Clotrimazole - adverse effects Clotrimazole - therapeutic use Drug Therapy, Combination Female Humans Metronidazole - adverse effects Metronidazole - therapeutic use Syndrome |
| title | Acute vanishing bile duct syndrome after therapy with cephalosporin, metronidazole, and clotrimazole: A case report |
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