IL1 Receptor Antagonist Controls Transcriptional Signature of Inflammation in Patients with Metastatic Breast Cancer

Inflammation affects tumor immune surveillance and resistance to therapy. Here, we show that production of IL1β in primary breast cancer tumors is linked with advanced disease and originates from tumor-infiltrating CD11c myeloid cells. IL1β production is triggered by cancer cell membrane-derived TGF...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2018-09, Vol.78 (18), p.5243-5258
Hauptverfasser:	Wu, Te-Chia, Xu, Kangling, Martinek, Jan, Young, Robyn R, Banchereau, Romain, George, Joshy, Turner, Jacob, Kim, Kyung In, Zurawski, Sandra, Wang, Xuan, Blankenship, Derek, Brookes, Hannah M, Marches, Florentina, Obermoser, Gerlinde, Lavecchio, Elizabeth, Levin, Maren K, Bae, Sookyoung, Chung, Cheng-Han, Smith, Jennifer L, Cepika, Alma-Martina, Oxley, Kyp L, Snipes, George J, Banchereau, Jacques, Pascual, Virginia, O'Shaughnessy, Joyce, Palucka, A Karolina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Capecitabine - administration & dosage CD11c Antigen - metabolism Cell Line, Tumor Cell Membrane - metabolism Female Furans - administration & dosage Gene Expression Regulation, Neoplastic Humans Inflammation Interleukin 1 Receptor Antagonist Protein - administration & dosage Interleukin 1 Receptor Antagonist Protein - metabolism Interleukin-1beta - metabolism Ketones - administration & dosage Leukocytes, Mononuclear - cytology Macrophages - metabolism Mice Mice, SCID Myeloid Cells - metabolism Neoplasm Metastasis Neoplasm Transplantation Paclitaxel - administration & dosage Pilot Projects Transcription, Genetic Transforming Growth Factor beta - metabolism
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