The unlikely partnership between LRRK2 and α‐synuclein in Parkinson's disease

Our understanding of the mechanisms underlying Parkinson's disease, the once archetypical nongenetic neurogenerative disorder, has dramatically increased with the identification of α‐synuclein and LRRK2 pathogenic mutations. While α‐synuclein protein composes the aggregates that can spread thro...

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Veröffentlicht in:	The European journal of neuroscience 2019-02, Vol.49 (3), p.339-363
Hauptverfasser:	Cresto, Noémie, Gardier, Camille, Gubinelli, Francesco, Gaillard, Marie‐Claude, Liot, Géraldine, West, Andrew B., Brouillet, Emmanuel
Format:	Artikel
Sprache:	eng
Schlagworte:	aggregation alpha-Synuclein - adverse effects alpha-Synuclein - genetics alpha-Synuclein - metabolism Animals autophagy Brain - metabolism Human health and pathology Humans Inflammation Kinases Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - adverse effects Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - genetics Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - metabolism Life Sciences LRRK2 protein mitochondria mitophagy Movement disorders Mutation Nerve Degeneration - metabolism Neurodegeneration Neurodegenerative diseases neuroinflammation Neurons - metabolism Neurons and Cognition Neurotoxicity Parkinson Parkinson Disease - genetics Parkinson Disease - metabolism Parkinson's disease Phosphotransferase prion‐like propagation Proteins Synuclein Tissues and Organs
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