Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance

Immune checkpoint inhibitors and adoptive transfer of gene-engineered T cells have emerged as novel therapeutic modalities for hard-to-treat solid tumors; however, many patients are refractory to these immunotherapies, and the mechanisms underlying tumor immune resistance have not been fully elucida...

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Veröffentlicht in:	The Journal of clinical investigation 2019-03, Vol.129 (3), p.1278-1294
Hauptverfasser:	Muraoka, Daisuke, Seo, Naohiro, Hayashi, Tae, Tahara, Yoshiro, Fujii, Keisuke, Tawara, Isao, Miyahara, Yoshihiro, Okamori, Kana, Yagita, Hideo, Imoto, Seiya, Yamaguchi, Rui, Komura, Mitsuhiro, Miyano, Satoru, Goto, Masahiro, Sawada, Shin-Ichi, Asai, Akira, Ikeda, Hiroaki, Akiyoshi, Kazunari, Harada, Naozumi, Shiku, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Adoptive Transfer Animals Antigen Presentation Antigens Antigens, Neoplasm - chemistry Antigens, Neoplasm - genetics Antigens, Neoplasm - immunology Antigens, Neoplasm - pharmacology Apoptosis Bioinformatics Biomedical research Cancer Cancer patients CD11b antigen Cell death Cytokines Cytotoxicity Drug Delivery Systems Female Genes Genotype & phenotype Health aspects Hydrogels Hydrogels - chemistry Hydrogels - pharmacology Hypoxia Immune checkpoint inhibitors Immune response Immunogenicity Immunology Immunotherapy Inflammation Lymphatic system Lymphocytes Lymphocytes T Macrophages Macrophages - immunology Macrophages - pathology Mice Mice, Inbred BALB C Mice, Knockout Nanoparticles - chemistry Neoplasms, Experimental - genetics Neoplasms, Experimental - immunology Neoplasms, Experimental - pathology Neoplasms, Experimental - therapy Peptides Permeability Phosphatase Proteins Solid tumors T cell receptors T cells T-Lymphocytes - immunology T-Lymphocytes - pathology T-Lymphocytes - transplantation Trabectedin Tumor Microenvironment - drug effects Tumor Microenvironment - genetics Tumors Vaccines
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