4′-Phosphopantetheine and long acyl chain-dependent interactions are integral to human mitochondrial acyl carrier protein function

The mitochondrial acyl carrier protein (human ACPM, yeast Acp1) is an essential mitochondrial protein. Through binding of nascent acyl chains on the serine (S112)-bound 4′-phosphopantetheine (4′-PP) cofactor, ACPM is involved in mitochondrial fatty acid synthesis and lipoic acid biogenesis. Recently...

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Veröffentlicht in:	MedChemComm 2019-02, Vol.1 (2), p.29-22
Hauptverfasser:	Majmudar, Jaimeen D, Feng, Xidong, Fox, Nicholas G, Nabhan, Joseph F, Towle, Theresa, Ma, Tiffany, Gooch, Renea, Bulawa, Christine, Yue, Wyatt W, Martelli, Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl carrier protein Binding Biosynthesis Chains Chemistry Clusters Coordination compounds Fatty acids Iron Lipoic acid Mass spectrometry Mass spectroscopy Mitochondria Proteins Serine Stability Sulfur Yeast
Online-Zugang:	Volltext
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