Mice harboring an MCTO mutation exhibit renal failure resembling nephropathy in human patients

Multicentric carpotarsal osteolysis (MCTO) is a condition involving progressive osteolysis of the carpal and tarsal bones that is associated with glomerular sclerosis and renal failure (MCTO nephropathy). Previous work identified an autosomal dominant missense mutation in the transactivation domain...

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Veröffentlicht in:	Experimental Animals 2019, Vol.68(1), pp.103-111
Hauptverfasser:	Tsunakawa, Yuki, Hamada, Michito, Matsunaga, Yurina, Fuseya, Sayaka, Jeon, Hyojung, Wakimoto, Yuji, Usui, Toshiaki, Kanai, Maho, Mizuno, Seiya, Morito, Naoki, Takahashi, Satoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Albuminuria Animals Biocompatibility Biomedical materials Body weight Body Weight - genetics Bones Clustered Regularly Interspaced Short Palindromic Repeats Creatinine Creatinine - urine CRISPR CRISPR-Associated Protein 9 Disease Models, Animal Feet focal segmental glomerulosclerosis Genetic transformation Glomerulosclerosis, Focal Segmental - genetics Glomerulosclerosis, Focal Segmental - therapy Humans MafB MafB Transcription Factor - genetics Mice Mice, Inbred C57BL Mice, Inbred ICR Mice, Mutant Strains Microvillus Mimicry Missense mutation multicentric carpotarsal osteolysis Mutation Mutation, Missense - genetics Nephropathy Original Osteolysis Osteolysis - genetics Osteolysis - therapy Pathogenesis Renal failure Renal Insufficiency - genetics Renal Insufficiency - therapy Sclerosis Side effects Signs and symptoms Transcriptional Activation - genetics Urine
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