Deficiency of the BMP Type I receptor ALK3 partly protects mice from anemia of inflammation

Inflammatory stimuli induce the hepatic iron regulatory hormone hepcidin, which contributes to anaemia of inflammation (AI). Hepcidin expression is regulated by the bone morphogenetic protein (BMP) and the interleukin-6 (IL-6) signalling pathways. Prior results indicate that the BMP type I receptor...

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Veröffentlicht in:	BMC physiology 2018-02, Vol.18 (1), p.3-3, Article 3
Hauptverfasser:	Gallitz, Inka, Lofruthe, Niklas, Traeger, Lisa, Bäumer, Nicole, Hoerr, Verena, Faber, Cornelius, Kuhlmann, Tanja, Müller-Tidow, Carsten, Steinbicker, Andrea U
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Anemia - complications Anemia - metabolism Animals Bone Morphogenetic Protein Receptors, Type I - deficiency Brucella abortus Brucellosis - complications Care and treatment Erythropoiesis Female Gene expression Hepatocytes - metabolism Inflammation - etiology Inflammation - metabolism Inflammation Mediators - metabolism Messenger RNA Mice, Inbred C57BL Phosphorylation Signal Transduction Smad1 Protein - metabolism Smad5 Protein - metabolism Smad8 Protein - metabolism STAT3 Transcription Factor - metabolism Transcription (Genetics)
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