The topology of the regulatory interactions predicts the expression pattern of the segment polarity genes in Drosophila melanogaster

Expression of the Drosophila segment polarity genes is initiated by a pre-pattern of pair-rule gene products and maintained by a network of regulatory interactions throughout several stages of embryonic development. Analysis of a model of gene interactions based on differential equations showed that...

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Veröffentlicht in:	Journal of theoretical biology 2003-07, Vol.223 (1), p.1-18
Hauptverfasser:	Albert, Réka, Othmer, Hans G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Proteins - genetics Boolean model Cleavage Stage, Ovum - physiology Complement C4 Computer Simulation Drosophila melanogaster - genetics Drosophila melanogaster - physiology Drosophila Proteins - genetics Drosophila segmentation Gene Expression Gene regulatory network Genes, Insect Genes, Regulator Membrane Proteins - genetics Models, Genetic Proto-Oncogene Proteins - genetics Receptors, Cell Surface Segment polarity genes Wnt1 Protein
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