Pulmonary neuroendocrine cells amplify allergic asthma responses

Pulmonary neuroendocrine cells (PNECs) are rare airway epithelial cells whose function is poorly understood. Here we show that -mutant mice that have no PNECs exhibit severely blunted mucosal type 2 response in models of allergic asthma. PNECs reside in close proximity to group 2 innate lymphoid cel...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2018-06, Vol.360 (6393)
Hauptverfasser:	Sui, Pengfei, Wiesner, Darin L, Xu, Jinhao, Zhang, Yan, Lee, Jinwoo, Van Dyken, Steven, Lashua, Amber, Yu, Chuyue, Klein, Bruce S, Locksley, Richard M, Deutsch, Gail, Sun, Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Allergens Allergies Allergy Alveoli Amines Amphibians Amplification Animal models Animals ASCL1 protein Asthma Asthma - immunology Asthma - pathology Basic Helix-Loop-Helix Transcription Factors - deficiency Basic Helix-Loop-Helix Transcription Factors - genetics Calcitonin Calcitonin gene-related peptide Calcitonin Gene-Related Peptide - metabolism Cell culture Chemical sensors Chemoreceptors Clustering Cytokines Cytokines - biosynthesis Deactivation Dense core vesicles Disease Models, Animal Effectors Epithelial cells Epithelial Cells - immunology Epithelial Cells - pathology Epithelium Feedback (Response) Female gamma-Aminobutyric Acid - biosynthesis gamma-Aminobutyric Acid - metabolism Goblet Cells - pathology House dust Humans Hyperplasia Hypersensitivity Immune response Immune system In vivo methods and tests Inactivation Interleukin 5 Lung - pathology Lungs Mice Modules Molecular chains Mucosa Mucous membrane Mucus Mutants Neuroendocrine Cells - immunology Neuroendocrine Cells - pathology Neuropeptides Neurotransmitters Numbers Patients Peptides Physiological responses Proximity Reptiles Respiratory tract Rodents Scientific Concepts Sensory neurons
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