Hepatic hexokinase domain containing 1 (HKDC1) improves whole body glucose tolerance and insulin sensitivity in pregnant mice

Hexokinase domain containing 1, a recently discovered putative fifth hexokinase, is hypothesized to play key roles in glucose metabolism. Specifically, during pregnancy in a recent genome wide association study (GWAS), a strong correlation between HKDC1 and 2-h plasma glucose in pregnant women from...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2019-03, Vol.1865 (3), p.678-687
Hauptverfasser:	Khan, Md. Wasim, Priyadarshini, Medha, Cordoba-Chacon, Jose, Becker, Thomas C., Layden, Brian T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbohydrate Metabolism - genetics Disease Models, Animal Energy Metabolism - genetics Female Gestational diabetes Glucose - metabolism Glucose Intolerance - genetics Glucose Intolerance - metabolism Glucose Intolerance - prevention & control HEK293 Cells Hexokinase Hexokinase - genetics Hexokinase - physiology Humans Insulin resistance Insulin Resistance - genetics Male Mice Mice, Inbred C57BL Mice, Transgenic Pregnancy Pregnancy Complications - genetics Pregnancy Complications - metabolism Pregnancy Complications - prevention & control
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