Potential for Drug Repositioning of Midazolam for Dentin Regeneration

Drug repositioning promises the advantages of reducing costs and expediting approvalschedules. An induction of the anesthetic and sedative drug; midazolam (MDZ), regulatesinhibitory neurotransmitters in the vertebrate nervous system. In this study we show the potentialfor drug repositioning of MDZ f...

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Veröffentlicht in:	International journal of molecular sciences 2019-02, Vol.20 (3), p.670
Hauptverfasser:	Karakida, Takeo, Onuma, Kazuo, Saito, Mari M, Yamamoto, Ryuji, Chiba, Toshie, Chiba, Risako, Hidaka, Yukihiko, Fujii-Abe, Keiko, Kawahara, Hiroshi, Yamakoshi, Yasuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline phosphatase Anesthesia Animal models Apoptosis Ascorbic acid Biomedical materials Bone morphogenetic protein 2 Bone morphogenetic proteins Caspase Cell cycle Cell differentiation Colorimetry Dental pulp Dentin Differentiation (biology) Endoplasmic reticulum Fibroblast growth factors Gene expression Glycerophosphate Growth factors Mesenchyme Midazolam Mineralization Nervous system Nodules Odontoblasts Osteoblastogenesis Osteoblasts Phagocytosis Phosphatase Proteins Regeneration Stains & staining Stem cells Studies Tissue engineering Transforming growth factor-b Transforming growth factor-b1 β-Glycerophosphoric acid
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