Leathesia difformis Extract Inhibits α-MSH-Induced Melanogenesis in B16F10 Cells via Down-Regulation of CREB Signaling Pathway

(L.) Areschoug ( ) is a species of littoral brown algae of the class Phaeophyceae. Only a few studies on the apoptotic, antiviral, and antioxidant properties of have been reported, and its inhibitory effect on melanin synthesis has not been studied. The aim of this study was to investigate the anti-...

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Veröffentlicht in:	International journal of molecular sciences 2019-01, Vol.20 (3), p.536
Hauptverfasser:	Seo, Ga-Young, Ha, Yuna, Park, Ah-Hyun, Kwon, Oh Wook, Kim, Youn-Jung
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Adrenocorticotropic hormone Algae alpha-MSH - pharmacology Animals Ascorbic acid Biosynthesis Cell Death - drug effects Cell Survival - drug effects Cyclic AMP - metabolism Cyclic AMP response element-binding protein Cyclic AMP Response Element-Binding Protein - metabolism Cytotoxicity Dermatitis Dihydroxyphenylalanine Down-regulation Down-Regulation - drug effects Endothelin 1 Endothelins Gene expression Gene Expression Regulation, Neoplastic - drug effects Hydroquinone Keratinocytes Kinases Kojic acid Melanin Melanins - biosynthesis Melanocortin Melanocyte-stimulating hormone Melanocytes Melanoma Melanoma, Experimental - metabolism Membrane proteins Mice Microphthalmia-associated transcription factor Models, Biological Monophenol Monooxygenase - metabolism mRNA Phaeophyceae - chemistry Pheomelanin Phosphorylation Phosphorylation - drug effects Pituitary Pituitary gland Proteins Reference Standards Retinoic acid RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction Skin Tyrosinase Ultraviolet radiation Xanthophylls - analysis
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