Rapamycin − mTOR + BRAF = ? Using relational similarity to find therapeutically relevant drug-gene relationships in unstructured text

[Display omitted] •Compare relational and attributional similarity to find drugs that target genes.•Use literature-derived Random Indexing and neural embedding to estimate similarity.•Relational similarity outperforms attributional similarity for this task.•Neural word embeddings model performs bett...

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Veröffentlicht in:	Journal of biomedical informatics 2019-02, Vol.90, p.103094-103094, Article 103094
Hauptverfasser:	Fathiamini, Safa, Johnson, Amber M., Zeng, Jia, Holla, Vijaykumar, Sanchez, Nora S., Meric-Bernstam, Funda, Bernstam, Elmer V., Cohen, Trevor
Format:	Artikel
Sprache:	eng
Schlagworte:	Attributional similarity Data Mining Humans Neural word embeddings Pharmacogenomics Precision oncology Proto-Oncogene Proteins B-raf - genetics Random Indexing Relational similarity Sirolimus - pharmacology TOR Serine-Threonine Kinases - genetics
Online-Zugang:	Volltext
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