Optimal design, anti-tumour efficacy and tolerability of anti-CXCR4 antibody drug conjugates

Antibody-drug conjugates (ADCs) are promising therapies for haematological cancers. Historically, their therapeutic benefit is due to ADC targeting of lineage-restricted antigens. The C - X - C motif chemokine r eceptor 4 (CXCR4) is attractive for targeted therapy of haematological cancers, given it...

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Veröffentlicht in:	Scientific reports 2019-02, Vol.9 (1), p.2443-2443, Article 2443
Hauptverfasser:	Costa, Maria José, Kudaravalli, Jyothirmayee, Ma, Jing-Tyan, Ho, Wei-Hsien, Delaria, Kathy, Holz, Charles, Stauffer, Angela, Chunyk, Allison Given, Zong, Qing, Blasi, Eileen, Buetow, Bernard, Tran, Thomas-Toan, Lindquist, Kevin, Dorywalska, Magdalena, Rajpal, Arvind, Shelton, David L., Strop, Pavel, Liu, Shu-Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	14 59/5 631/154/51 631/67/1990 64/60 692/4028/67/1059/153 82/1 96/106 96/31 Affinity Antigens Blood cancer Bone cancer Bone marrow Cancer Chemokines CXCR4 protein Drug delivery Drug development Hematology Hematopoietic stem cells Humanities and Social Sciences multidisciplinary Science Science (multidisciplinary) Solid tumors Stem cells Toxicity Xenografts
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