CRISPR/Cas9-Mediated Knockout of DNAJC14 Verifies This Chaperone as a Pivotal Host Factor for RNA Replication of Pestiviruses

Pestiviruses like bovine viral diarrhea virus (BVDV) are a threat to livestock. For pestiviruses, cytopathogenic (cp) and noncytopathogenic (noncp) strains are distinguished in cell culture. The noncp biotype of BVDV is capable of establishing persistent infections, which is a major problem in disea...

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Veröffentlicht in:	Journal of virology 2019-03, Vol.93 (5)
Hauptverfasser:	Isken, O, Postel, A, Bruhn, B, Lattwein, E, Becher, P, Tautz, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bovine Virus Diarrhea-Mucosal Disease - virology Cattle Cattle Diseases - virology Cell Line CRISPR-Cas Systems - genetics Diarrhea Virus 1, Bovine Viral - genetics Fetal Proteins - genetics Gene Knockout Techniques Genome and Regulation of Viral Gene Expression Genome, Viral - genetics HEK293 Cells Humans Molecular Chaperones - genetics Molecular Chaperones - metabolism RNA Helicases - genetics RNA Helicases - metabolism RNA, Viral - biosynthesis RNA, Viral - genetics Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Swine Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism Virus Replication - genetics
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