Effects of altered pyruvate dehydrogenase activity on contracting skeletal muscle bioenergetics

During aerobic exercise (>65% of maximum oxygen consumption), the primary source of acetyl-CoA to fuel oxidative ATP synthesis in muscle is the pyruvate dehydrogenase (PDH) reaction. This study investigated how regulation of PDH activity affects muscle energetics by determining whether activation...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2019-01, Vol.316 (1), p.R76-R86
Hauptverfasser:	Kasper, Jonathan D, Meyer, Ronald A, Beard, Daniel A, Wiseman, Robert W
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation energy Adenosine diphosphate Adenosine triphosphatase Adenosine Triphosphate - metabolism Animals Bioenergetics Chemical synthesis Dehydrogenase Dichloroacetic acid Effects Energy Metabolism - drug effects Enzymes Free energy Gastrocnemius muscle Glycolysis Hydrolysis Magnetic resonance spectroscopy Male Metabolites Mitochondria Muscle contraction Muscle Contraction - drug effects Muscle, Skeletal - drug effects Muscle, Skeletal - enzymology Muscles Musculoskeletal system NMR Nuclear fuels Nuclear magnetic resonance Oxidation-Reduction - drug effects Oxidoreductases - drug effects Oxygen consumption Oxygen Consumption - drug effects Oxygen Consumption - physiology Phosphocreatine Phosphorus Physiological effects Pyruvate Dehydrogenase Complex - metabolism Pyruvate Dehydrogenase Complex - pharmacology Pyruvic acid Rats, Wistar Skeletal muscle Spectrum analysis Steady state Stimulation
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